Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201526 | 0.91 | ABL1 (0.35) | RIPK1SYKP2RX3RIPK2RIPK3 | |
| SCHEMBL22201519 | 0.88 | SYK (0.40) | RIPK1SYKP2RX3KMT2ARIPK2 | |
| SCHEMBL22201563 | 0.86 | P2RX3 (0.38) | SYKP2RX3KDM4EMEN1KMT2A | |
| SCHEMBL22201402 | 0.83 | MEN1 (0.36) | SYKP2RX3KDM4EMEN1KMT2A | |
| SCHEMBL22201404 | 0.83 | P2RX3 (0.38) | P2RX3KDM4EMEN1KMT2AROCK2 | |
| SCHEMBL22201401 | 0.83 | KDM4E (0.36) | SYKP2RX3KDM4EMEN1KMT2A | |
| SCHEMBL22201400 | 0.82 | KMT2A (0.37) | SYKP2RX3KDM4EMEN1KMT2A | |
| SCHEMBL22201399 | 0.82 | MEN1 (0.37) | SYKP2RX3KDM4EMEN1KMT2A | |
| SCHEMBL22201565 | 0.82 | KDM4E (0.35) | P2RX3KDM4EMEN1KMT2AROCK2 | |
| SCHEMBL22201403 | 0.79 | ROCK2 (0.35) | P2RX3KDM4EMEN1KMT2AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |