Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201566 | 0.89 | KDM4E (0.40) | GRM4CYP1A2ROCK2ADORA3ALDH1A1 | |
| SCHEMBL22201586 | 0.81 | PRKCH (0.47) | LMNAHPGDMAPTROCK2ALDH1A1 | |
| SCHEMBL22201617 | 0.81 | LMNA (0.48) | LMNAHPGDMAPTALDH1A1POLB | |
| SCHEMBL22201258 | 0.81 | ABCG2 (0.48) | LMNAHPGDMAPTABCG2 | |
| SCHEMBL22201537 | 0.78 | KDM4E (0.42) | LMNAHPGDMAPTGRM4CYP1A2 | |
| SCHEMBL22201559 | 0.78 | HPGD (0.58) | LMNAHPGDMAPTALDH1A1POLB | |
| SCHEMBL22201692 | 0.78 | KDM4E (0.44) | LMNAHPGDMAPTALDH1A1POLB | |
| SCHEMBL22201323 | 0.76 | SYK (0.38) | HPGDMAPTGRM4CYP1A2KDM4E | |
| SCHEMBL22201494 | 0.76 | JAK2 (0.36) | LMNAHPGDMAPTGRM4CYP1A2 | |
| SCHEMBL22201368 | 0.74 | SYK (0.45) | GRM4CYP1A2ADORA3ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |