Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | PRKCH | P24723 | 2/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201489 | 0.90 | SYK (0.37) | SYKPRKCHPRKCEMAPTHPGD | |
| SCHEMBL22201488 | 0.90 | ADORA3 (0.37) | SYKPRKCHPRKCEPRKCQPRKCD | |
| SCHEMBL22201492 | 0.89 | P2RX3 (0.32) | SYKPRKCHPRKCEMAPTHPGD | |
| SCHEMBL22201485 | 0.89 | ULK1 (0.40) | SYKMAPTHPGDLMNATGFBR1 | |
| SCHEMBL22201324 | 0.88 | ADORA3 (0.39) | SYKPRKCHPRKCELMNAGRM4 | |
| SCHEMBL22201531 | 0.88 | ABL1 (0.38) | SYKTGFBR1KDM4E | |
| SCHEMBL22201326 | 0.87 | ULK1 (0.40) | MAPTHPGDLMNATGFBR1ABCG2 | |
| SCHEMBL22201273 | 0.86 | SYK (0.37) | SYKMAPTHPGDGRM4TGFBR1 | |
| SCHEMBL22201366 | 0.86 | MAPT (0.39) | SYKMAPTHPGDLMNAABCG2 | |
| SCHEMBL22201586 | 0.86 | PRKCH (0.47) | SYKPRKCHPRKCEMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |