Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | PRKCH | P24723 | 1/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201655 | 0.91 | PRKCH (0.48) | TGFBR1MKNK1PRKCHPRKCEROCK2 | |
| SCHEMBL22201257 | 0.83 | FGFR2 (0.62) | TGFBR1PRKCHPRKCEEGFRFLT1 | |
| SCHEMBL22201261 | 0.81 | ACP1 (0.54) | TGFBR1CLK1EGFRFLT1ROCK2 | |
| SCHEMBL1642794 | 0.78 | FGFR2 (0.72) | MKNK1CLK1EGFRFLT1ROCK2 | |
| SCHEMBL22201393 | 0.78 | ABCG2 (0.55) | TGFBR1MKNK1ROCK2 | |
| SCHEMBL16941497 | 0.77 | HPGD (0.65) | TGFBR1PRKCHPRKCEROCK2ROCK1 | |
| SCHEMBL22201450 | 0.77 | PRKCH (0.51) | TGFBR1PRKCHPRKCEEGFRFGFR2 | |
| SCHEMBL22201282 | 0.76 | HPGD (0.64) | PRKCHPRKCEEGFR | |
| SCHEMBL22201396 | 0.75 | TGFBR1 (0.53) | TGFBR1MKNK1CLK1ROCK2ROCK1 | |
| SCHEMBL8788878 | 0.74 | CLK1 (0.58) | MKNK1CLK1ROCK2ROCK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |