SCHEMBL22201865

SCHEMBL22201865

CC(C)(CC(O)COc1ccc(CC2NC(=O)C(Cc3ccc(OC(C)(C)CC4CO4)cc3)NC2=O)cc1)Oc1ccc(CC2NC(=O)C(Cc3ccc(OCC4CO4)cc3)NC2=O)cc1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.38
TP53 P04637 2/20 0.38
MAPT P10636 2/20 0.38
HPGD P15428 2/20 0.38
TSHR P16473 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 2/20 0.38
CYP1A2 P05177 1/20 0.38
HIF1A Q16665 1/20 0.38
HRH3 Q9Y5N1 5/20 0.35
PKM P14618 2/20 0.34
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.34
TDP1 Q9NUW8 1/20 0.32
CASR P41180 1/20 0.31
MMP1 P03956 1/20 0.30
MMP9 P14780 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22201844 0.93 TP53 (0.33) PPARGTP53MAPTHPGDTSHR
SCHEMBL25937503 0.84 ALDH1A1 (0.44) PPARGTP53MAPTHPGDTSHR
SCHEMBL22106293 0.83 KMT2A (0.60) PPARGTP53MAPTHPGDTSHR
SCHEMBL25937947 0.80 PPARG (0.40) PPARGTP53MAPTHPGDTSHR
SCHEMBL24714975 0.79 ALDH1A1 (0.47) PPARGTP53MAPTHPGDTSHR
SCHEMBL25917990 0.79 MEN1 (0.40) PPARGTP53MAPTHPGDTSHR
SCHEMBL22201743 0.78 ALDH1A1 (0.53) PPARGTP53MAPTHPGDTSHR
SCHEMBL22191192 0.78 ALDH1A1 (0.53) PPARGTP53MAPTHPGDTSHR
SCHEMBL25937500 0.76 ALDH1A1 (0.37) PPARGTP53MAPTHPGDTSHR
SCHEMBL13464372 0.76 TP53 (0.41) PPARGTP53MAPTHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242491-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS ZYMERGEN INC. (US) 2023-08-03 US disclosed
WO-2022006023-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS ZYMERGEN INC. (US) 2022-01-06 WO disclosed
WO-2020142450-A1 POLYMER COMPOSITIONS COMPRISING COMPOUNDS DERIVED FROM BIOLOGY ZYMERGEN INC. (US) 2020-07-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242491-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS HDHD5, HAO2, ALAD PPARG 1623/4885TP53 324/4885MAPT 2075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.