Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6227347 | 0.85 | RAB9A (0.59) | RAB9AKMT2AMEN1ALDH1A1CYP2C19 | |
| Bromide SCHEMBL1193996 | 0.84 | RAB9A (0.58) | RAB9AKMT2AMEN1ALDH1A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL287745 | 0.82 | ALDH1A1 (0.43) | RAB9AHDAC3KMT2AHSP90AA1MEN1 | |
| SCHEMBL6225447 | 0.81 | RAB9A (0.42) | RAB9AHDAC3KMT2AMEN1ALDH1A1 | |
| SCHEMBL6228170 | 0.81 | RAB9A (0.48) | RAB9AKMT2AHSP90AA1MEN1ALDH1A1 | |
| SCHEMBL30206621 | 0.81 | RAB9A (0.42) | RAB9AHDAC3KMT2AMEN1ALDH1A1 | |
| SCHEMBL6229031 | 0.81 | KMT2A (0.49) | RAB9AKMT2AHSP90AA1MEN1ALDH1A1 | |
| Bromide SCHEMBL1194277 | 0.80 | GLA (0.42) | RAB9AHDAC3KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28477049 | 0.80 | RAB9A (0.41) | RAB9AHDAC3KMT2AMEN1ALDH1A1 | |
| Bromide SCHEMBL29494160 | 0.80 | GLA (0.42) | RAB9AHDAC3KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717727-B2 | Pyridinium compounds | TORRENT PHARMACEUTICALS LIMITED (IN) | 2020-07-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10717727-B2 | Pyridinium compounds | CYP3A5, PLPBP, PDXK | RAB9A 3699/4885HDAC3 1821/4885KMT2A 3736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.