Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | APP | P05067 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222292 | 0.92 | S1PR1 (0.44) | S1PR1BRD4MAPK14 | |
| SCHEMBL2223727 | 0.92 | S1PR1 (0.47) | S1PR1ALOX5SMN1; SMN2APPALDH1A1 | |
| SCHEMBL2222899 | 0.90 | S1PR1 (0.51) | S1PR1GRIN2BPTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL2222186 | 0.89 | S1PR1 (0.48) | S1PR1APPALDH1A1HPGDTP53 | |
| SCHEMBL2225559 | 0.85 | S1PR1 (0.49) | S1PR1APPALDH1A1HPGDTP53 | |
| SCHEMBL2223599 | 0.85 | S1PR1 (0.47) | S1PR1APPTP53BRD4CETP | |
| SCHEMBL14797018 | 0.85 | S1PR1 (0.65) | S1PR1GRIN2BSMN1; SMN2CETPMAPT | |
| SCHEMBL2222588 | 0.84 | S1PR1 (0.52) | S1PR1SMN1; SMN2APPALDH1A1HPGD | |
| SCHEMBL2223699 | 0.84 | S1PR1 (0.45) | S1PR1APPALDH1A1TP53CETP | |
| SCHEMBL2224913 | 0.84 | S1PR1 (0.47) | S1PR1APPALDH1A1HPGDCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523962-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086079-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |