Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236104 | 0.81 | RXFP1 (0.47) | HDAC1NPC1FLT1KDRROCK2 | |
| SCHEMBL13993635 | 0.80 | CDK14 (0.52) | — | |
| SCHEMBL22236099 | 0.78 | NAMPT (0.53) | MEN1KMT2ANPC1LMNAPKM | |
| SCHEMBL22235826 | 0.78 | WNT1 (0.46) | AURKAAURKBCLK2CLK3DYRK1A | |
| SCHEMBL22236264 | 0.77 | WNT1 (0.46) | AURKAAURKBCLK2CLK3DYRK1A | |
| SCHEMBL22235752 | 0.77 | CDK5 (0.43) | HTR2CCLK2CLK3DYRK1A | |
| SCHEMBL22236040 | 0.74 | FLT1 (0.42) | FLT1KDRNAMPT | |
| SCHEMBL22258286 | 0.74 | MAPT (0.49) | MEN1KMT2ANPC1LMNAFLT1 | |
| SCHEMBL22236103 | 0.74 | DDR1 (0.44) | HDAC1NPC1FLT1KDR | |
| SCHEMBL22236222 | 0.74 | RXFP1 (0.49) | MEN1KMT2ANPC1LMNAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |