Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239486 | 0.79 | MAP3K12 (0.41) | MAP3K12 | |
| SCHEMBL22123225 | 0.78 | MAP3K12 (0.45) | PROKR1MAP3K12 | |
| SCHEMBL20798062 | 0.76 | HRH4 (0.38) | HRH4 | |
| SCHEMBL3229097 | 0.76 | HRH4 (0.42) | HRH4 | |
| SCHEMBL19771672 | 0.74 | HRH4 (0.41) | HRH4 | |
| SCHEMBL3214532 | 0.74 | HRH4 (0.41) | HRH4 | |
| SCHEMBL16211905 | 0.74 | SPR (0.37) | MAP3K12 | |
| SCHEMBL22239461 | 0.73 | ALDH1A1 (0.43) | PDE4BPROKR1MAP3K12 | |
| SCHEMBL16220115 | 0.72 | TRPV3 (0.46) | PDE4B | |
| SCHEMBL3852030 | 0.72 | CYP17A1 (0.34) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991977-B1 | C-LINKED HETEROCYCLOALKYL SUBSTITUTED PYRIMIDINES AND THEIR USES | HOFFMANN LA ROCHE (CH) | 2020-07-22 | — | — | EP | disclosed |