Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503089 | 0.81 | HTT (0.42) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL22246384 | 0.77 | KMT2A (0.34) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL1564745 | 0.75 | TDP1 (0.34) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL2366190 | 0.75 | LMNA (0.37) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL17298243 | 0.75 | NOS3 (0.38) | KMT2AHTTL3MBTL1MAPTNQO1 | |
| SCHEMBL24550677 | 0.75 | HTT (0.38) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL1565399 | 0.75 | LMNA (0.44) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL23832162 | 0.70 | POLB (0.47) | KMT2AHTTL3MBTL1POLBMAPT | |
| SCHEMBL24551214 | 0.70 | HEXA (0.36) | KMT2AL3MBTL1POLBMEN1ALDH1A1 | |
| SCHEMBL10397963 | 0.70 | NQO2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9655965-B2 | Radiosensitizer compounds for use in combination with radiation | Lu qing-bin (CA) | 2017-05-23 | — | — | US | disclosed |
| US-20160235743-A1 | NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY | Lu qing-bin (CA) | 2016-08-18 | — | — | US | disclosed |
| US-20150343059-A1 | RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION | Lu qing-bin (CA) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150343059-A1 | RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION | RB1, ERCC2, RBBP7 | KMT2A 1657/4885HTT 3997/4885L3MBTL1 2999/4885 |
| US-20160235743-A1 | NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY | TOP2B, POLR2B, RB1 | KMT2A 1600/4885HTT 3018/4885L3MBTL1 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.