Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | PGK2 | P07205 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18243308 | 0.81 | PGK1 (0.38) | TSHRPGK1PGK2 | |
| SCHEMBL1847239 | 0.81 | TSHR (0.61) | TSHRPGK1PGK2CYP1A2 | |
| SCHEMBL18242030 | 0.78 | PGK1 (0.35) | TSHRPGK1PGK2 | |
| SCHEMBL2223264 | 0.77 | TSHR (0.30) | TSHR | |
| SCHEMBL2091605 | 0.76 | TSHR (0.35) | TSHRPGK1PGK2 | |
| SCHEMBL18243451 | 0.76 | PGK1 (0.34) | TSHRPGK1PGK2 | |
| Hydrochloric Acid SCHEMBL19409801 | 0.76 | TSHR (0.55) | TSHRPGK1PGK2CYP1A2 | |
| SCHEMBL349313 | 0.75 | HDAC8 (0.47) | TSHR | |
| SCHEMBL97209 | 0.75 | TSHR (0.54) | TSHR | |
| SCHEMBL2223817 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210087163-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2021-03-25 | — | — | US | claimed |
| EP-2544535-B1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIV (US) | 2017-04-19 | — | — | EP | claimed |
| US-9617239-B2 | Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2017-04-11 | — | — | US | claimed |
| US-20160237058-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2016-08-18 | — | — | US | claimed |
| US-20130345196-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2013-12-26 | — | — | US | claimed |
| US-20130345235-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2013-12-26 | — | — | US | claimed |
| EP-2544535-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | North Carolina Central University (US) | 2013-01-16 | — | — | EP | claimed |
| WO-2011112858-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-09-15 | — | — | WO | claimed |
| WO-2011084503-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-07-14 | — | — | WO | claimed |
| CN-115335464-A | Hydrophobic coating composition | 迈图高新材料公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-113423767-A | Silicone-based curable compositions and their use cross-reference to related applications | 迈图高新材料公司 | 2021-09-21 | — | — | CN | disclosed |
| CN-113366044-A | Silicone-based curable composition and use thereof | 迈图高新材料公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-113348204-A | Silicone-based curable compositions and their use cross-reference to related applications | 迈图高新材料公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-110494464-B | Oligomeric polyol compositions | 美国主席团有限公司 | 2021-06-15 | — | — | CN | disclosed |
| WO-2011112858-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-09-15 | — | — | WO | disclosed |
| WO-2011084503-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2011-07-14 | — | — | WO | disclosed |
| CN-1294129-C | Heteraryl-substituted porrole derivatives, their prep. and therapeutic use | SANKYO CO (JP) | 2007-01-10 | — | — | CN | disclosed |
| EP-0262399-B1 | CYCLIC ENOL DERIVATIVES, PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 1993-02-03 | — | — | EP | disclosed |
| US-4925868-A | CARDIOVASCULAR DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-05-15 | — | — | US | disclosed |
| EP-0262399-A2 | Cyclic enol derivatives, production and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1988-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345235-A1 | PHENOXY THIOPHENE SULFONAMIDES AND THEIR USE AS INHIBITORS OF GLUCURONIDASE | CES2, TOP1, GUSB | TSHR 2411/4885PGK1 858/4885PGK2 638/4885 |
| US-20160237058-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | TOP2A, TOP1, PNP | TSHR 3958/4885PGK1 886/4885PGK2 549/4885 |
| US-20130345196-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | TOP2A, TOP1, TOP2B | TSHR 3777/4885PGK1 1017/4885PGK2 588/4885 |
| US-20210087163-A1 | PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE | TOP2A, TOP1, PNP | TSHR 3958/4885PGK1 886/4885PGK2 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.