Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28141491 | 0.83 | ESR1 (0.34) | HDAC8HDAC4HDAC2KIF11ESR1 | |
| SCHEMBL127219 | 0.81 | ESR1 (0.38) | HDAC8HDAC4HDAC2KIF11ACHE | |
| SCHEMBL129151 | 0.81 | HDAC8 (0.56) | HDAC8HDAC4HDAC2KIF11ACHE | |
| Water SCHEMBL29289408 | 0.78 | HDAC8 (0.54) | HDAC8HDAC4HDAC2KIF11ACHE | |
| SCHEMBL2223264 | 0.77 | TSHR (0.30) | TSHR | |
| SCHEMBL28324137 | 0.76 | TSHR (0.50) | ALDH1A1L3MBTL1TSHRNOTUM | |
| SCHEMBL97209 | 0.75 | TSHR (0.54) | ALDH1A1TDP1GAAMAPTTSHR | |
| SCHEMBL2224945 | 0.75 | TSHR (0.48) | TSHR | |
| SCHEMBL2223817 | 0.75 | — | — | |
| SCHEMBL125514 | 0.74 | MAPT (0.42) | HDAC8HDAC4HDAC2ACHERXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024104384-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO. LTD. (CN) | 2024-05-23 | — | — | WO | claimed |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | claimed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | claimed |
| EP-4185564-A1 | TRICYCLIC HETEROCYCLES | Merck Patent GmbH (DE) | 2023-05-31 | — | — | EP | claimed |
| CN-116134016-A | Tricyclic heterocycles | 默克专利股份公司 | 2023-05-16 | — | — | CN | claimed |
| WO-2023078813-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | MERCK PATENT GMBH (DE) | 2023-05-11 | — | — | WO | claimed |
| EP-4146652-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | Merck Patent GmbH (DE) | 2023-03-15 | — | — | EP | claimed |
| CN-115515959-A | Tricyclic heterocycles as TEAD binders | 默克专利股份公司 | 2022-12-23 | — | — | CN | claimed |
| CN-114160210-A | Catalyst for selective tetramerization of ethylene and preparation method and application thereof | 华东理工大学 | 2022-03-11 | — | — | CN | claimed |
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | claimed |
| CN-113600241-A | Catalyst system for selective trimerization of ethylene and preparation and application thereof | 华东理工大学 | 2021-11-05 | — | — | CN | claimed |
| US-20210277014-A1 | (S)-3-(2-(4-(BENZYL)-3-OXOPIPERAZIN-1-YL)ACETAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CASPASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | HISTOGEN, INC. | 2021-09-09 | — | — | US | claimed |
| EP-3814327-A1 | (S)-3-(2-(4-(BENZYL)-3-OXOPIPERAZIN-1-YL)ACETAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CASPASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | Histogen, Inc. (US) | 2021-05-05 | — | — | EP | claimed |
| EP-2411564-B1 | ELECTROCHEMICAL PROCESS FOR PRODUCING 3-TERT-BUTYLBENZALDEHYDE-DIMETHYLACETAL | BASF SE (DE) | 2017-05-10 | — | — | EP | claimed |
| US-8629304-B2 | Electrochemical method for producing 3-tert-butylbenzaldehyde dimethyl acetal | BASF SE (DE) | 2014-01-14 | — | — | US | claimed |
| US-20120016162-A1 | ELECTROCHEMICAL METHOD FOR PRODUCING 3-TERT-BUTYLBENZALDEHYDE DIMETHYL ACETAL | BASF SE (DE) | 2012-01-19 | — | — | US | claimed |
| WO-2009038412-A2 | BETA-SECRETASE INHIBITING COMPOUNDS | LG LIFE SCIENCES, LTD. (KR) | 2009-03-26 | — | — | WO | claimed |
| US-12012475-B2 | Method of olefin polymerization using alkane-soluble non-metallocene precatalyst | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-06-18 | — | — | US | disclosed |
| US-3988471-A | Insect control employing certain benzoates | CHEVRON RESEARCH COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
| US-3936462-A | CNS DEPRESSANT, ANALGESIC | STERLING DRUG INC. (US) | 1976-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277014-A1 | (S)-3-(2-(4-(BENZYL)-3-OXOPIPERAZIN-1-YL)ACETAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CASPASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | CASP1, CASP3, CASP6 | HDAC8 709/4885HDAC4 445/4885HDAC2 307/4885 |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | HDAC8 871/4885HDAC4 1943/4885HDAC2 2216/4885 |
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | HDAC8 773/4885HDAC4 1608/4885HDAC2 1990/4885 |
| US-20120016162-A1 | ELECTROCHEMICAL METHOD FOR PRODUCING 3-TERT-BUTYLBENZALDEHYDE DIMETHYL ACETAL | TET3, TERT, ALKBH2 | HDAC8 691/4885HDAC4 832/4885HDAC2 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.