Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 12/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13505428 | 0.79 | MTNR1A (0.43) | HTR6NAMPT | |
| SCHEMBL2224241 | 0.76 | HTR1A (0.47) | HTR1AHTR1DHTR2C | |
| SCHEMBL16551399 | 0.71 | NAMPT (0.41) | ABCC9ABCC8KCNJ11KCNJ8HTR6 | |
| SCHEMBL2223467 | 0.70 | NQO2 (0.46) | ABCC9ABCC8KCNJ11KCNJ8HTR6 | |
| SCHEMBL2226805 | 0.69 | ALOX15 (0.41) | HTR1AHTR1DHTR2CMEN1KMT2A | |
| SCHEMBL4569736 | 0.69 | PTGDR (0.40) | HTR2CHTR6PTGDR2PTGER2MEN1 | |
| SCHEMBL16444560 | 0.67 | MAOB (0.37) | HTR1AHTR1DHTR2CMEN1KMT2A | |
| SCHEMBL16551637 | 0.67 | MTNR1A (0.43) | PTGDR2 | |
| SCHEMBL16443954 | 0.66 | LMNA (0.36) | HTR1AHTR1DHTR2CMEN1KMT2A | |
| SCHEMBL16551778 | 0.65 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011087712-A2 | TRICYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | CEPHALON, INC. (US) | 2011-07-21 | — | — | WO | disclosed |