SCHEMBL2226474

SCHEMBL2226474

NC(=O)c1cnc2c(c1)C=NCN2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NNMT P40261 9/20 0.51
HPGDS O60760 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PSMD14 O00487 1/20 0.33
STAMBP O95630 1/20 0.33
COPS5 Q92905 1/20 0.33
F7 P08709 1/20 0.32
F3 P13726 1/20 0.32
SARM1 Q6SZW1 1/20 0.32
SIRT2 Q8IXJ6 1/20 0.32
SIRT6 Q8N6T7 1/20 0.32
SIRT1 Q96EB6 1/20 0.32
SIRT3 Q9NTG7 1/20 0.32
SIRT5 Q9NXA8 1/20 0.32
SIRT4 Q9Y6E7 1/20 0.32
LMNA P02545 1/20 0.31
CHEK2 O96017 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31
MYC P01106 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2425564 0.86 MGAM (0.36) NNMTPSMD14LMNAKDM4E
SCHEMBL30445575 0.78 NNMT (0.51) NNMTHPGDSSMN1; SMN2PSMD14STAMBP
SCHEMBL35211576 0.76 NNMT (0.45) NNMTHPGDSSMN1; SMN2PSMD14STAMBP
SCHEMBL2115737 0.73 SIRT2 (0.37) NNMTSIRT2CHEK2MKNK1MKNK2
SCHEMBL2116598 0.71 TSHR (0.38) F7F3SARM1SIRT2SIRT6
SCHEMBL25352498 0.70 NNMT (0.57) NNMTHPGDSSMN1; SMN2PSMD14STAMBP
SCHEMBL25787975 0.70 NNMT (0.66) NNMTHPGDSSMN1; SMN2PSMD14STAMBP
SCHEMBL25787741 0.68 NNMT (1.00) NNMTSMN1; SMN2PSMD14STAMBPCOPS5
SCHEMBL35211895 0.66 ADORA3 (0.36) NNMTSIRT6LMNA
SCHEMBL25787747 0.66 NNMT (1.00) NNMTSMN1; SMN2CHRNB2CHRNA4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2521726-A1 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES SANOFI (FR) 2012-11-14 EP claimed
WO-2011086306-A9 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D] PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES SANOFI-AVENTIS (FR) 2011-10-27 WO claimed
WO-2011086306-A1 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D] PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES SANOFI-AVENTIS (FR) 2011-07-21 WO claimed
EP-2521726-A1 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES SANOFI (FR) 2012-11-14 EP disclosed