Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.41 |
| ▸ | LPL | P06858 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22264962 | 1.00 | CYP1A2 (0.44) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL22264805 | 0.86 | ALDH2 (0.41) | LIPGLPLALDH1A1HPGDKDM4E | |
| SCHEMBL22273380 | 0.86 | ALDH2 (0.41) | LIPGLPLALDH1A1HPGDKDM4E | |
| SCHEMBL18343416 | 0.84 | OGG1 (0.41) | LIPGLPLALDH1A1HPGDKDM4E | |
| SCHEMBL31188697 | 0.84 | CYP1A2 (0.51) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL15376138 | 0.84 | LIPG (0.46) | GAALIPGLPLALDH1A1KDM4E | |
| SCHEMBL4106141 | 0.83 | LIPG (0.39) | LIPGLPLP4HBCA1CA2 | |
| SCHEMBL28654967 | 0.82 | LIPG (0.42) | LIPGLPLP4HBCA1CA2 | |
| SCHEMBL25330900 | 0.81 | LIPG (0.44) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL25330897 | 0.81 | LIPG (0.44) | LIPGLPLCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3914256-B1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES INC (US) | 2024-05-29 | — | — | EP | disclosed |
| US-11773101-B2 | GPR35 modulators | PROMETHEUS BIOSCIENCES, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210380590-A1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES, INC. | 2021-12-09 | — | — | US | disclosed |
| EP-3914256-A1 | GPR35 MODULATORS | Prometheus Biosciences, Inc. (US) | 2021-12-01 | — | — | EP | disclosed |
| CN-113631168-A | GPR35 modulators | 普罗米修斯生物科学公司 | 2021-11-09 | — | — | CN | disclosed |
| US-11053251-B2 | GPR35 modulators | PROMETHEUS BIOSCIENCES, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| WO-2020154492-A1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| US-20200239476-A1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES, INC. | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380590-A1 | GPR35 MODULATORS | GPR35, GPR55, GPR65 | CYP1A2 1872/4885GAA 1742/4885CYP2C9 3236/4885 |
| US-11053251-B2 | GPR35 modulators | GPR35, GPR55, GPR65 | CYP1A2 1872/4885GAA 1742/4885CYP2C9 3236/4885 |
| US-11773101-B2 | GPR35 modulators | GPR35, GPR55, GPR65 | CYP1A2 1872/4885GAA 1742/4885CYP2C9 3236/4885 |
| US-20200239476-A1 | GPR35 MODULATORS | GPR35, GPR55, GPR65 | CYP1A2 1872/4885GAA 1742/4885CYP2C9 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.