Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | GAA | P10253 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 6/20 | 0.33 |
| ▸ | CASP1 | P29466 | 6/20 | 0.33 |
| ▸ | CASP7 | P55210 | 6/20 | 0.33 |
| ▸ | GLA | P06280 | 5/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.31 |
| ▸ | CA2 | P00918 | 4/20 | 0.31 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA7 | P43166 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12723239 | 0.80 | TSHR (0.39) | HSD17B10KDM4EGAAALDH1A1HPGD | |
| SCHEMBL13621985 | 0.75 | TSHR (0.35) | HSD17B10TSHRKMT2ATDP1MAPK1 | |
| SCHEMBL1970857 | 0.75 | TSHR (0.35) | HSD17B10TSHRKMT2ATDP1MAPK1 | |
| SCHEMBL638361 | 0.75 | TSHR (0.35) | HSD17B10TSHRKMT2ATDP1MAPK1 | |
| SCHEMBL12228858 | 0.74 | ALDH1A1 (0.38) | HSD17B10KDM4EGAAALDH1A1HPGD | |
| SCHEMBL28684469 | 0.69 | HSP90AB1 (0.37) | HSD17B10GAAALDH1A1TSHRKMT2A | |
| SCHEMBL25753203 | 0.68 | TLR4 (0.38) | HSD17B10KDM4EGAAALDH1A1HPGD | |
| SCHEMBL22272897 | 0.68 | KDM4E (0.36) | HSD17B10KDM4EGAAALDH1A1HPGD | |
| SCHEMBL818870 | 0.67 | KDM4E (0.32) | HSD17B10KDM4EGAAALDH1A1HPGD | |
| SCHEMBL819759 | 0.66 | KCNH2 (0.34) | HSD17B10KDM4EGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630364-B1 | HYDROXY DERIVATIVES OF CYCLOHEXADIENE | ZENECA LTD (GB) | 1997-08-27 | — | — | EP | disclosed |
| US-5508444-A | Cyclic compounds | ZENECA LIMITED (GB) | 1996-04-16 | — | — | US | disclosed |
| WO-1993017994-A1 | HYDROXY DERIVATIVES OF CYCLOHEXADIENE | ZENECA LIMITED (GB) | 1993-09-16 | — | — | WO | disclosed |