Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22272928 | 0.83 | TYK2 (0.39) | TYK2PDE4D | |
| SCHEMBL22272925 | 0.83 | TYK2 (0.39) | TYK2PDE4D | |
| SCHEMBL22272916 | 0.80 | TYK2 (0.56) | TYK2PDE4D | |
| SCHEMBL22272929 | 0.79 | TYK2 (0.62) | TYK2PDE4D | |
| SCHEMBL22272906 | 0.78 | TYK2 (0.55) | TYK2 | |
| SCHEMBL22273237 | 0.78 | TYK2 (0.50) | TYK2 | |
| SCHEMBL22252393 | 0.67 | MALT1 (0.36) | AAK1 | |
| SCHEMBL22425951 | 0.65 | MALT1 (0.35) | — | |
| SCHEMBL24263264 | 0.64 | TYK2 (0.64) | TYK2PDE4D | |
| SCHEMBL22252388 | 0.63 | LMNA (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154474-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-07-30 | — | — | WO | disclosed |