Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280462 | 0.79 | SPHK2 (0.67) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL19033692 | 0.77 | SPHK1 (0.72) | RAB9ANPC1ALDH1A1LMNAHPGD | |
| SCHEMBL22280284 | 0.76 | ALDH1A1 (0.55) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL22265570 | 0.75 | SPHK1 (0.69) | SPHK2SPHK1 | |
| SCHEMBL22280465 | 0.73 | RAB9A (0.60) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL22280439 | 0.73 | RAB9A (0.60) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL22280297 | 0.72 | MAPK1 (0.64) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL22280266 | 0.72 | MAPK1 (0.64) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL22280458 | 0.72 | ALDH1A1 (0.54) | RAB9ANPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL22280454 | 0.72 | ALDH1A1 (0.54) | RAB9ANPC1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |