Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.44 |
| ▸ | RAB9A | P51151 | 12/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179259 | 0.92 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL18583800 | 0.81 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL18261865 | 0.74 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL24725804 | 0.71 | NISCH (0.35) | — | |
| SCHEMBL22331935 | 0.70 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL20867446 | 0.68 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL3341124 | 0.68 | PARP1 (0.67) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL7395837 | 0.68 | HDAC6 (0.59) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL25726668 | 0.68 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL28117058 | 0.66 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210387978-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | US | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210387978-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | NPC1 572/4885RAB9A 1107/4885SMN1; SMN2 263/4885 |
| US-20200239441-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | NPC1 633/4885RAB9A 215/4885SMN1; SMN2 890/4885 |
| US-11236069-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | NPC1 633/4885RAB9A 215/4885SMN1; SMN2 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.