Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2511327 | 0.83 | MRGPRX4 (0.45) | GPR35MRGPRX4XDHSLC22A12 | |
| SCHEMBL2170685 | 0.79 | MRGPRX4 (0.49) | GPR35MRGPRX4XDHSLC22A12EGLN2 | |
| SCHEMBL1421486 | 0.77 | VNN1 (0.39) | — | |
| SCHEMBL2228843 | 0.77 | HCAR1 (0.52) | TTR | |
| SCHEMBL2228769 | 0.76 | RXRA (0.45) | MEN1KMT2A | |
| SCHEMBL30300320 | 0.74 | POLB (0.42) | GPR35MRGPRX4XDHSLC22A12TTR | |
| SCHEMBL5222297 | 0.74 | POLB (0.42) | GPR35MRGPRX4XDHSLC22A12TTR | |
| SCHEMBL4788616 | 0.74 | KDM4E (0.46) | GPR35MRGPRX4XDHEGLN2 | |
| SCHEMBL31455773 | 0.74 | KDM4E (0.46) | GPR35MRGPRX4XDHEGLN2 | |
| SCHEMBL2224262 | 0.72 | RXRA (0.45) | MEP1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088181-A9 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| EP-2533783-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011088181-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |