Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 6/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353367 | 0.83 | ALDH1A1 (0.60) | RXRARXRBALDH1A1BCL2DAO | |
| SCHEMBL334347 | 0.79 | RXRA (0.64) | RXRARXRBALDH1A1BCL2DAO | |
| SCHEMBL23279535 | 0.77 | KDM4E (0.49) | RXRARXRBALDH1A1LOXL2 | |
| SCHEMBL2228843 | 0.77 | HCAR1 (0.52) | ALDH1A1TPMT | |
| SCHEMBL2228769 | 0.76 | RXRA (0.45) | RXRAMEN1KMT2ATPMTPTGS2 | |
| SCHEMBL2228040 | 0.76 | ALDH1A1 (0.52) | RXRARXRBALDH1A1BCL2DAO | |
| SCHEMBL27646038 | 0.76 | ALDH1A1 (0.52) | RXRARXRBALDH1A1BCL2DAO | |
| SCHEMBL2228271 | 0.72 | GPR35 (0.39) | MEP1BMEN1KMT2A | |
| SCHEMBL22396426 | 0.72 | CES2 (0.46) | RXRARXRB | |
| SCHEMBL22396440 | 0.72 | KMT2A (0.49) | RXRARXRBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088181-A9 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| EP-2533783-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011088181-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |