Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22284769 | 0.82 | KDM4E (0.32) | KDM4ERAB9AMAPTNPC1HPGD | |
| SCHEMBL22284700 | 0.78 | CYP11B2 (0.36) | KDM4ERAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL22708305 | 0.77 | PTGS1 (0.35) | PTGS1KDM4ERAB9AMAPTNPC1 | |
| SCHEMBL22284555 | 0.74 | PTGS1 (0.49) | PTGS1KDM4ERAB9AMAPTNPC1 | |
| SCHEMBL378249 | 0.71 | — | — | |
| SCHEMBL22299283 | 0.69 | FBP1 (0.40) | PTGS1KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL22284683 | 0.64 | APP (0.30) | MAPT | |
| SCHEMBL31656609 | 0.63 | — | — | |
| SCHEMBL4365342 | 0.62 | — | — | |
| SCHEMBL1842897 | 0.59 | SMN1; SMN2 (0.31) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548873-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2023-01-10 | — | — | US | claimed |
| US-20210078979-A1 | PYRAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2021-03-18 | — | — | US | claimed |
| US-10882846-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2021-01-05 | — | — | US | claimed |
| US-20200247782-A1 | PYRAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2020-08-06 | — | — | US | claimed |
| EP-3921307-B1 | PYRAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2024-06-26 | — | — | EP | disclosed |
| US-11851420-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2023-12-26 | — | — | US | disclosed |
| US-20230114845-A1 | PYRAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2023-04-13 | — | — | US | disclosed |
| US-11548873-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2023-01-10 | — | — | US | disclosed |
| US-10947219-B2 | Enantioselective process for the manufacture of lactam carboxylate derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2021-03-16 | — | — | US | disclosed |
| US-10865197-B2 | Enantioselective process for manufacture | SYNGENTA CROP PROTECTION AG (CH) | 2020-12-15 | — | — | US | disclosed |
| US-10851085-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2020-12-01 | — | — | US | disclosed |
| US-10800759-B2 | — | — | 2020-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11851420-B2 | Pyrazole derivatives | RB1, CBR3, CYP1B1 | PTGS1 2860/4885KDM4E 597/4885RAB9A 494/4885 |
| US-10882846-B2 | Pyrazole derivatives | RB1, CBR3, CYP1B1 | PTGS1 2860/4885KDM4E 597/4885RAB9A 494/4885 |
| US-10851085-B2 | Pyrazole derivatives | RB1, RBBP5, RBBP7 | PTGS1 4128/4885KDM4E 1324/4885RAB9A 925/4885 |
| US-20200247782-A1 | PYRAZOLE DERIVATIVES | RB1, CBR3, CYP1B1 | PTGS1 2860/4885KDM4E 597/4885RAB9A 494/4885 |
| US-10947219-B2 | Enantioselective process for the manufacture of lactam carboxylate derivatives | UBE2D3, SBDS, MRPL21 | PTGS1 4102/4885KDM4E 391/4885RAB9A 444/4885 |
| US-10865197-B2 | Enantioselective process for manufacture | RB1, RBX1, RBBP4 | PTGS1 3128/4885KDM4E 65/4885RAB9A 474/4885 |
| US-20230114845-A1 | PYRAZOLE DERIVATIVES | RB1, CBR3, CYP1B1 | PTGS1 2860/4885KDM4E 597/4885RAB9A 494/4885 |
| US-20210078979-A1 | PYRAZOLE DERIVATIVES | RB1, CBR3, CYP1B1 | PTGS1 2860/4885KDM4E 597/4885RAB9A 494/4885 |
| US-11548873-B2 | Pyrazole derivatives | RB1, CBR3, CYP1B1 | PTGS1 2860/4885KDM4E 597/4885RAB9A 494/4885 |
| US-10800759-B2 | — | RB1, RBBP5, CCNC | PTGS1 4197/4885KDM4E 875/4885RAB9A 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.