Sugi Predict

Sugi Predict / Compounds / SCHEMBL22285654

SCHEMBL22285654

SCHEMBL22285654

N#Cc1cccc(C(F)(F)C(=O)O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTPN5 P54829 1/20 0.46
▸ PDK1 Q15118 1/20 0.44
▸ PDK2 Q15119 1/20 0.44
▸ PDK3 Q15120 1/20 0.44
▸ PDK4 Q16654 1/20 0.44
▸ PTGDR2 Q9Y5Y4 1/20 0.44
▸ KIF11 P52732 1/20 0.43
▸ GSK3B P49841 2/20 0.42
▸ XDH P47989 1/20 0.42
▸ SLC22A12 Q96S37 1/20 0.42
▸ NOTUM Q6P988 2/20 0.41
▸ TAS2R14 Q9NYV8 1/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.41
▸ PTPN1 P18031 2/20 0.41
▸ ENPP2 Q13822 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ RXRA P19793 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL27502598 0.85 FFAR1 (0.52) PTPN5PDK1PDK2PDK3PDK4
Lithium Ion SCHEMBL30953330 0.83 PTPN5 (0.43) PTPN5PDK1PDK2PDK3PDK4
SCHEMBL29810563 0.83 PDK1 (0.49) PTPN5PDK1PDK2PDK3PDK4
SCHEMBL28846029 0.83 PDK1 (0.49) PTPN5PDK1PDK2PDK3PDK4
Trifluoroacetic Acid SCHEMBL16673835 0.82 FFAR1 (0.51) PTPN5PDK1PDK2PDK3PDK4
SCHEMBL13199336 0.81 PGK1 (0.48) PTPN5SLC22A12PTPN1MEN1ALDH1A1
SCHEMBL3937789 0.79 SGK1 (0.47) PDK1PDK2PDK3PDK4KIF11
SCHEMBL12004125 0.78 KIF11 (0.52) PTPN5PTGDR2KIF11
SCHEMBL22649196 0.78 PTPN5 (0.41) PTPN5PDK1PDK2PDK3PDK4
SCHEMBL29421430 0.77 KIF11 (0.50) PTPN5PTGDR2KIF11RXFP1ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234225-B2 IL-17 ligands and uses thereof DICE ALPHA, INC. (US) 2025-02-25 — — US disclosed
WO-2024208228-A1 NOVEL COMPOUNDS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF NUPHASE THERAPEUTICS (HANGZHOU) LIMITED., CO. (CN) 2024-10-10 — — WO disclosed
CN-113874080-B IL-17A modulators and uses thereof 戴斯阿尔法公司 2024-09-27 — — CN disclosed
CN-118390080-A Method for preparing fluorine-containing aromatic hydrocarbon carboxylic acid by electrocatalytic fixation of carbon dioxide 上海第二工业大学 2024-07-26 — — CN disclosed
US-20230145481-A1 SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS DICE ALPHA, INC. 2023-05-11 — — US disclosed
US-20230141212-A1 SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS DICE ALPHA, INC. 2023-05-11 — — US disclosed
US-20230145481-A1 SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS DICE ALPHA, INC. 2023-05-11 — — US disclosed
US-20230141212-A1 SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS DICE ALPHA, INC. 2023-05-11 — — US disclosed
US-20230053746-A1 IL-17 LIGANDS AND USES THEREOF DICE MOLECULES SV, INC. 2023-02-23 — — US disclosed
US-11447468-B2 IL-17 ligands and uses thereof DICE ALPHA, INC. (US) 2022-09-20 — — US disclosed
US-11274094-B2 Substituted benzenecarboxamides as IL-17A modulators DICE ALPHA, INC. (US) 2022-03-15 — — US disclosed
CN-113874080-A IL-17A modulators and uses thereof 戴斯阿尔法公司 2021-12-31 — — CN disclosed
EP-3921038-A1 IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2021-12-15 — — EP disclosed
US-20210101886-A1 IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. 2021-04-08 — — US disclosed
WO-2021055376-A1 IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. (US) 2021-03-25 — — WO disclosed
WO-2020163554-A1 IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. (US) 2020-08-13 — — WO disclosed
US-20200247785-A1 IL-17 Ligands And Uses Thereof DICE MOLECULES SV, INC. 2020-08-06 — — US disclosed
US-20200247785-A1 IL-17 Ligands And Uses Thereof DICE MOLECULES SV, INC. 2020-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230053746-A1 IL-17 LIGANDS AND USES THEREOF IL17A, IL2, IL15 PTPN5 567/4885PDK1 3029/4885PDK2 3085/4885
US-11447468-B2 IL-17 ligands and uses thereof IL17A, IL2, IL15 PTPN5 567/4885PDK1 3029/4885PDK2 3085/4885
US-20230145481-A1 SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS IL17A, IL2, IL23R PTPN5 964/4885PDK1 2064/4885PDK2 1556/4885
US-11274094-B2 Substituted benzenecarboxamides as IL-17A modulators IL17A, IL23R, IL18 PTPN5 993/4885PDK1 2520/4885PDK2 2027/4885
US-20230141212-A1 SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS IL17A, IL2, IL23R PTPN5 964/4885PDK1 2064/4885PDK2 1556/4885
US-20200247785-A1 IL-17 Ligands And Uses Thereof IL17A, IL2, IL15 PTPN5 567/4885PDK1 3029/4885PDK2 3085/4885
US-12234225-B2 IL-17 ligands and uses thereof IL17A, IL2, IL15 PTPN5 567/4885PDK1 3029/4885PDK2 3085/4885
US-20210101886-A1 IL-17A MODULATORS AND USES THEREOF IL17A, IL2, IL36G PTPN5 401/4885PDK1 2283/4885PDK2 2857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.