Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244829 | 0.87 | FDPS (0.36) | MEN1ALDH1A1KMT2AFDPS | |
| SCHEMBL12196377 | 0.87 | FDPS (0.36) | MEN1ALDH1A1KMT2AFDPS | |
| SCHEMBL2846893 | 0.87 | FDPS (0.36) | MEN1ALDH1A1KMT2AFDPS | |
| SCHEMBL3868579 | 0.85 | TSHR (0.33) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL2200625 | 0.85 | ALDH1A1 (0.38) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL8030539 | 0.85 | TSHR (0.33) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL580695 | 0.85 | ALDH1A1 (0.38) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL9180645 | 0.83 | ALDH1A1 (0.37) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL9344562 | 0.81 | ALDH1A1 (0.35) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL9181624 | 0.81 | ALDH1A1 (0.35) | MEN1ALDH1A1CYP1A2THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118834175-A | Benzothiazacycloalkanes Heptatriene compounds use thereof as bile acid modulators | 阿尔比里奥公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-113453753-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-114761080-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-07-23 | — | — | CN | disclosed |
| US-11891368-B2 | Benzothia(di)azepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2024-02-06 | — | — | US | disclosed |
| EP-4069361-B1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2024-01-03 | — | — | EP | disclosed |
| US-11773071-B2 | Benzothiazepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2023-10-03 | — | — | US | disclosed |
| EP-3921027-B1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2023-07-19 | — | — | EP | disclosed |
| EP-4069361-A1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | Albireo AB (SE) | 2022-10-12 | — | — | EP | disclosed |
| CN-114761080-A | Benzothia (di) azepin compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2022-07-15 | — | — | CN | disclosed |
| US-20220162176-A1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2022-05-26 | — | — | US | disclosed |
| US-11267794-B2 | Benzothia(di)azepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2022-03-08 | — | — | US | disclosed |
| EP-3921027-A1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | Albireo AB (SE) | 2021-12-15 | — | — | EP | disclosed |
| CN-113453753-A | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2021-09-28 | — | — | CN | disclosed |
| WO-2021110886-A1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2021-06-10 | — | — | WO | disclosed |
| US-20210171481-A1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2021-06-10 | — | — | US | disclosed |
| US-20210147372-A1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2021-05-20 | — | — | US | disclosed |
| US-10975045-B2 | Benzothiazepine compounds and their use as bile acid modulators | Aibireo AB (SE) | 2021-04-13 | — | — | US | disclosed |
| WO-2020161216-A1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2020-08-13 | — | — | WO | disclosed |
| US-20200247768-A1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267794-B2 | Benzothia(di)azepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | MEN1 4013/4885ALDH1A1 1005/4885CYP1A2 401/4885 |
| US-11773071-B2 | Benzothiazepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | MEN1 4561/4885ALDH1A1 706/4885CYP1A2 292/4885 |
| US-20200247768-A1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | SLC10A1, SLC10A2, ABCB11 | MEN1 4561/4885ALDH1A1 706/4885CYP1A2 292/4885 |
| US-20220162176-A1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | SLC10A1, SLC10A2, ABCB11 | MEN1 4013/4885ALDH1A1 1005/4885CYP1A2 401/4885 |
| US-20210147372-A1 | BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | SLC10A1, SLC10A2, ABCB11 | MEN1 4561/4885ALDH1A1 706/4885CYP1A2 292/4885 |
| US-20210171481-A1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | SLC10A1, SLC10A2, ABCB11 | MEN1 4013/4885ALDH1A1 1005/4885CYP1A2 401/4885 |
| US-11891368-B2 | Benzothia(di)azepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | MEN1 4013/4885ALDH1A1 1005/4885CYP1A2 401/4885 |
| US-10975045-B2 | Benzothiazepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | MEN1 4561/4885ALDH1A1 706/4885CYP1A2 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.