Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 6/20 | 0.32 |
| ▸ | PPARD | Q03181 | 6/20 | 0.32 |
| ▸ | PPARA | Q07869 | 6/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | TLR2 | O60603 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | FABP4 | P15090 | 2/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846893 | 1.00 | FDPS (0.36) | FDPSCYP4F2CYP4A11ALDH1A1AKR1B1 | |
| SCHEMBL12196377 | 1.00 | FDPS (0.36) | FDPSCYP4F2CYP4A11ALDH1A1AKR1B1 | |
| SCHEMBL6843155 | 0.91 | AKR1B1 (0.36) | ALDH1A1AKR1B1GPR84FFAR1PPARG | |
| SCHEMBL22286374 | 0.87 | MEN1 (0.33) | FDPSALDH1A1MEN1KMT2A | |
| SCHEMBL28125208 | 0.87 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1AKR1B1GPR84 | |
| SCHEMBL120634 | 0.87 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1AKR1B1GPR84 | |
| SCHEMBL392507 | 0.87 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1AKR1B1GPR84 | |
| SCHEMBL9645707 | 0.86 | CYP4F2 (0.34) | FDPSCYP4F2CYP4A11ALDH1A1AKR1B1 | |
| SCHEMBL680541 | 0.85 | CYP4F2 (0.38) | CYP4F2CYP4A11ALDH1A1AKR1B1GPR84 | |
| SCHEMBL8921783 | 0.85 | CYP4F2 (0.38) | CYP4F2CYP4A11ALDH1A1AKR1B1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4188541-B1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2024-12-25 | — | — | EP | disclosed |
| CN-118834175-A | Benzothiazacycloalkanes Heptatriene compounds use thereof as bile acid modulators | 阿尔比里奥公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-114786773-B | Benzothiazaheterocycles Heptatriene compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-10-18 | — | — | CN | disclosed |
| CN-114761080-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-113453753-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-07-23 | — | — | CN | disclosed |
| US-12024495-B2 | Benzothiazepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2024-07-02 | — | — | US | disclosed |
| CN-112449637-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-03-19 | — | — | CN | disclosed |
| US-11891368-B2 | Benzothia(di)azepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2024-02-06 | — | — | US | disclosed |
| EP-4069361-B1 | BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS | ALBIREO AB (SE) | 2024-01-03 | — | — | EP | disclosed |
| US-11773071-B2 | Benzothiazepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2023-10-03 | — | — | US | disclosed |
| US-20040147774-A1 | Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | US | disclosed |
| US-20040077625-A1 | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake | PHARMACIA CORPORATION | 2004-04-22 | — | — | US | disclosed |
| US-20020183307-A1 | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake | G.D. SEARLE LLC | 2002-12-05 | — | — | US | disclosed |
| US-6465451-B1 | Hypolipidemic benzothiazepine compounds | SMITHKLINE BEECHAM CORPORATION | 2002-10-15 | — | — | US | disclosed |
| WO-2002008211-A2 | BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS | G.D. SEARLE, LLC. (US) | 2002-01-31 | — | — | WO | disclosed |
| EP-1045840-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2000-10-25 | — | — | EP | disclosed |
| EP-0792268-B1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | WELLCOME FOUND (GB) | 2000-02-23 | — | — | EP | disclosed |
| US-5998400-A | Hypolipidemic benzothiazepines | GLAXO WELLCOME INC. (US) | 1999-12-07 | — | — | US | disclosed |
| WO-1999035135-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |
| WO-1996016051-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773071-B2 | Benzothiazepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | FDPS 1296/4885CYP4F2 450/4885CYP4A11 175/4885 |
| US-12024495-B2 | Benzothiazepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | FDPS 1296/4885CYP4F2 450/4885CYP4A11 175/4885 |
| US-20040077625-A1 | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake | SLC10A1, ABCB11, SLC10A2 | FDPS 1791/4885CYP4F2 373/4885CYP4A11 222/4885 |
| US-20020183307-A1 | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake | SLC10A1, SLC10A2, ABCB11 | FDPS 2843/4885CYP4F2 307/4885CYP4A11 212/4885 |
| US-20040147774-A1 | Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid | HCAR2, FFAR2, HCAR3 | FDPS 307/4885CYP4F2 327/4885CYP4A11 97/4885 |
| US-11891368-B2 | Benzothia(di)azepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | FDPS 1621/4885CYP4F2 1041/4885CYP4A11 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.