Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7735034 | 0.91 | NPC1 (0.51) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9833804 | 0.83 | RAB9A (0.44) | KMT2ANPC1RAB9ASMN1; SMN2SMYD3 | |
| SCHEMBL5392135 | 0.81 | RAB9A (0.62) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8161568 | 0.81 | NPC1 (0.87) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22289346 | 0.79 | NPC1 (0.84) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22308180 | 0.79 | NPC1 (0.84) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2983895 | 0.79 | NPC1 (0.84) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9834832 | 0.78 | NPC1 (0.53) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22308695 | 0.78 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22308692 | 0.78 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677334-B | Transient receptor potential MELASTATIN 8 (TRPM 8) antagonists and related methods | 马歇尔大学科研协会 | 2024-04-09 | — | — | CN | disclosed |
| US-20220313629-A1 | TRANSIENT POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | MARSHALL UNIVERSITY RESEARCH CORPORATION | 2022-10-06 | — | — | US | disclosed |
| EP-3917510-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | Marshall University Research Corporation (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-113677334-A | Transient receptor potential MELASTATIN 8(TRPM8) antagonists and related methods | 马歇尔大学科研协会 | 2021-11-19 | — | — | CN | disclosed |
| WO-2020160464-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | MARSHALL UNIVERSITY RESEARCH CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160464-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | MARSHALL UNIVERSITY RESEARCH CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220313629-A1 | TRANSIENT POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | TRPM8, TRPV1, TRPM7 | MEN1 1452/4885KMT2A 1511/4885NPC1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.