Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023373 | 0.81 | DGAT1 (0.39) | DGAT1HIF1AAAK1FFAR1PRMT5 | |
| SCHEMBL22289520 | 0.81 | FFAR1 (0.42) | DGAT1HIF1AAAK1FFAR1PRMT5 | |
| SCHEMBL24023421 | 0.79 | DGAT1 (0.42) | DGAT1HIF1AAAK1FFAR1PRMT5 | |
| SCHEMBL1476168 | 0.78 | DGAT1 (0.38) | DGAT1HIF1AAAK1PRMT5WDR77 | |
| SCHEMBL22977685 | 0.77 | DGAT1 (0.38) | DGAT1HIF1AAAK1FFAR1PRMT5 | |
| SCHEMBL23597018 | 0.76 | FFAR1 (0.44) | DGAT1HIF1AAAK1FFAR1PRMT5 | |
| SCHEMBL16008825 | 0.76 | FFAR1 (0.40) | DGAT1HIF1AFFAR1LIPGLPL | |
| SCHEMBL30523101 | 0.76 | FFAR1 (0.40) | DGAT1HIF1AFFAR1LIPGLPL | |
| SCHEMBL22185786 | 0.75 | LPL (0.40) | DGAT1HIF1AAAK1FFAR1LIPG | |
| SCHEMBL22312167 | 0.74 | CCR9 (0.35) | CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917513-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | Capulus Therapeutics, LLC (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020159889-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | CAPULUS THERAPEUTICS, LLC (US) | 2020-08-06 | — | — | WO | disclosed |