Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.33 |
| ▸ | LPL | P06858 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023421 | 0.84 | DGAT1 (0.42) | DGAT1HIF1APRMT5WDR77FFAR1 | |
| SCHEMBL22289552 | 0.81 | DGAT1 (0.45) | DGAT1HIF1APRMT5WDR77FFAR1 | |
| SCHEMBL22289520 | 0.79 | FFAR1 (0.42) | DGAT1HIF1APRMT5WDR77FFAR1 | |
| SCHEMBL18274832 | 0.79 | HIF1A (0.39) | DGAT1HIF1AGSK3AGSK3BUCHL1 | |
| SCHEMBL21201415 | 0.77 | LPL (0.37) | DGAT1HIF1APRMT5WDR77FFAR1 | |
| SCHEMBL16065191 | 0.76 | UCHL1 (0.42) | DGAT1HIF1AGSK3AGSK3BUCHL1 | |
| SCHEMBL24023322 | 0.75 | HSD11B1 (0.39) | GSK3AGSK3BHSD11B1LMNAMAPK1 | |
| SCHEMBL23597018 | 0.75 | FFAR1 (0.44) | DGAT1HIF1APRMT5WDR77FFAR1 | |
| SCHEMBL16008825 | 0.74 | FFAR1 (0.40) | DGAT1HIF1AFFAR1LIPGLPL | |
| SCHEMBL30523101 | 0.74 | FFAR1 (0.40) | DGAT1HIF1AFFAR1LIPGLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | PIK3CA, AKT3, GSK3B | DGAT1 3422/4885HIF1A 1495/4885PRMT5 3716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.