Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 3/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17263270 | 0.85 | ALPL (0.41) | ALPLALDH1A1L3MBTL1HSD17B10MAP2K4 | |
| SCHEMBL22290171 | 0.77 | LMNA (0.50) | ALDH1A1L3MBTL1MAP2K4MAPT | |
| SCHEMBL24987818 | 0.76 | SCN9A (0.44) | CDC7DBF4ALPLALDH1A1SCN10A | |
| SCHEMBL30511946 | 0.75 | SLC6A3 (0.47) | CDC7DBF4ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL580981 | 0.75 | KDM4E (0.56) | ALPLL3MBTL1ALOX15MAPT | |
| Hydrochloric Acid SCHEMBL580879 | 0.74 | KDM4E (0.55) | ALPLL3MBTL1ALOX15MAPT | |
| SCHEMBL31590542 | 0.73 | ALPL (0.41) | ALPLALDH1A1SCN9A | |
| SCHEMBL18003707 | 0.73 | CDC7 (0.46) | CDC7DBF4ALPLALDH1A1CNR1 | |
| SCHEMBL9907683 | 0.73 | HTR5A (0.56) | CDC7DBF4HTR5AALDH1A1MAP2K4 | |
| SCHEMBL22290204 | 0.73 | NISCH (0.41) | CDC7DBF4HTR5AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2021-12-16 | — | — | US | disclosed |
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2021-12-16 | — | — | US | disclosed |
| EP-3917919-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLH, POLB | CDC7 268/4885DBF4 3190/4885ALPL 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.