Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424894 | 0.86 | — | — | |
| SCHEMBL1290747 | 0.82 | ITGB3 (0.51) | ITGB3ITGA2BTPSAB1TPSD1TPSG1 | |
| SCHEMBL15270205 | 0.82 | EPHX1 (0.52) | TPSAB1TPSD1TPSG1TDP1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL20771047 | 0.81 | ITGB3 (0.50) | ITGB3ITGA2BTPSAB1TPSD1TPSG1 | |
| SCHEMBL1037980 | 0.81 | ALOX15 (0.47) | ITGB3ITGA2BTPSAB1TPSD1TPSG1 | |
| SCHEMBL1082190 | 0.81 | NOS2 (0.42) | ITGB3ITGA2BTPSAB1TPSD1TPSG1 | |
| SCHEMBL1440608 | 0.80 | EPHX1 (0.59) | TDP1SIGMAR1TSHREPHX1 | |
| SCHEMBL7350548 | 0.80 | TDP1 (0.72) | ITGB3ITGA2BTDP1CHRM1ALOX15 | |
| Hydrochloric Acid SCHEMBL7417264 | 0.79 | ALOX15 (0.46) | ITGB3ITGA2BTPSAB1TPSD1TPSG1 | |
| SCHEMBL16011477 | 0.79 | ITGB3 (0.46) | ITGB3ITGA2BTPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059218-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2025-02-20 | — | — | US | disclosed |
| CN-113677350-B | ENPP1 inhibitors and methods of modulating immune responses | 里兰斯坦福初级大学理事会 | 2025-01-14 | — | — | CN | disclosed |
| US-20220289775-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-15 | — | — | US | disclosed |
| EP-3917536-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | The Board of Trustees of the Leland Stanford Junior University (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-113677350-A | ENPP1 inhibitors and methods of modulating immune responses | 里兰斯坦福初级大学理事会 | 2021-11-19 | — | — | CN | disclosed |
| WO-2020160333-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289775-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | ENPP1, STING1, ENPP2 | ITGB3 4836/4885ITGA2B 4655/4885TPSAB1 967/4885 |
| US-20250059218-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | ENPP1, STING1, ENPP2 | ITGB3 4836/4885ITGA2B 4655/4885TPSAB1 967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.