SCHEMBL222956

SCHEMBL222956

Nc1c(I)cc([N+](=O)[O-])cc1I

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.67
LMNA P02545 3/20 0.61
HTT P42858 2/20 0.61
MEN1 O00255 1/20 0.61
KMT2A Q03164 1/20 0.61
ALDH1A1 P00352 7/20 0.56
POLB P06746 1/20 0.52
CYP3A4 P08684 3/20 0.50
CYP19A1 P11511 1/20 0.48
TSHR P16473 2/20 0.44
GPR35 Q9HC97 1/20 0.44
TDP1 Q9NUW8 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7032612 0.87 ALDH1A1 (0.63) XDHLMNAHTTMEN1KMT2A
SCHEMBL11291855 0.86 HTT (0.62) XDHLMNAHTTMEN1KMT2A
SCHEMBL3297288 0.86 XDH (0.57) XDHLMNAHTTMEN1KMT2A
SCHEMBL11754281 0.86 ALDH1A1 (0.74) XDHLMNAHTTMEN1KMT2A
SCHEMBL11753742 0.86 ALDH1A1 (0.67) XDHLMNAHTTMEN1KMT2A
SCHEMBL21618379 0.81 XDH (0.53) XDHLMNAHTTMEN1KMT2A
SCHEMBL11404334 0.81 XDH (1.00) XDHLMNAHTTMEN1KMT2A
SCHEMBL8018399 0.80 LMNA (0.67) XDHLMNAHTTMEN1KMT2A
SCHEMBL8589797 0.80 XDH (0.55) XDHLMNAHTTMEN1KMT2A
SCHEMBL15325683 0.78 XDH (0.50) XDHLMNAHTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0070198-B1 RADIATION-SENSITIVE COMPOSITION AND PATTERN-FORMATION METHOD USING THE SAME Hitachi, Ltd. (JP) 1985-06-19 EP claimed
EP-0070198-A1 Radiation-sensitive composition and pattern-formation method using the same Hitachi, Ltd. (JP) 1983-01-19 EP claimed
US-12636379-B2 Microbubble-chemotherapeutic agent complex for sonodynamic therapy Sonotarg Limited (GB) 2026-05-26 US disclosed
CN-119823106-A Enhanced nucleic acid polymerization by aromatic compounds 豪夫迈·罗氏有限公司 2025-04-15 CN disclosed
WO-2025034034-A1 NOVEL COMPOUND, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER OR TUMORS COMPRISING SAME 주식회사 대웅제약 2025-02-13 WO disclosed
CN-114144520-B Enhanced nucleic acid polymerization by aromatic compounds 豪夫迈·罗氏有限公司 2024-12-13 CN disclosed
CN-111771001-B Enhanced nucleic acid polymerization by aromatic compounds F·霍夫曼-罗氏股份公司 2024-09-06 CN disclosed
US-11970731-B2 Enhancement of nucleic acid polymerization by aromatic compounds Roche Sequencing Solutions, Inc. (US) 2024-04-30 US disclosed
EP-3735409-B1 ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS STRATOS GENOMICS INC (US) 2023-06-21 EP disclosed
US-20220347314-A1 MICROBUBBLE-CHEMOTHERAPEUTIC AGENT COMPLEX FOR SONODYNAMIC THERAPY UNIVERSITY OF ULSTER (GB) 2022-11-03 US disclosed
US-11382987-B2 Microbubble-chemotherapeutic agent complex for sonodynamic therapy UNIVERSITY OF ULSTER (GB) 2022-07-12 US disclosed
WO-1989001160-A1 NEW BIFUNCTIONAL PHOTOEXCITABLE REAGENTS, THEIR PREPARATION AND USE, IN PARTICULAR FOR PHOTOAFFINITY LABELLING CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) 1989-02-09 WO disclosed
EP-0070198-B1 RADIATION-SENSITIVE COMPOSITION AND PATTERN-FORMATION METHOD USING THE SAME Hitachi, Ltd. (JP) 1985-06-19 EP disclosed
EP-0118093-A1 Trichloroacryloyl urea derivatives, process for their preparation and their use as fungicides in agriculture and horticulture NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1984-09-12 EP disclosed
US-4465768-A Pattern-formation method with iodine containing azide and oxygen plasma etching of substrate HITACHI, LTD. (JP) 1984-08-14 US disclosed
US-4411912-A Insecticidal isovaleric acid esters ZOECON CORPORATION (US) 1983-10-25 US disclosed
EP-0070198-A1 Radiation-sensitive composition and pattern-formation method using the same Hitachi, Ltd. (JP) 1983-01-19 EP disclosed
US-4243819-A Substituted amino acids ZOECON CORPORATION (US) 1981-01-06 US disclosed
US-4053527-A REACTING HALONITROANILINES WITH ALCOHOLS AND NITROSATING AGENTS ION BASF AKTIENGESELLSCHAFT (DT) 1977-10-11 US disclosed
US-3978040-A Process for the preparation of cyanoazo compounds by reacting halogenoazo compounds with CuCN in an aqueous media in the presence of a nitrogen base BAYER AKTIENGESELLSCHAFT (DT) 1976-08-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12636379-B2 Microbubble-chemotherapeutic agent complex for sonodynamic therapy SON, BID, BCL2 XDH 2182/4885LMNA 1973/4885HTT 1297/4885
US-20220347314-A1 MICROBUBBLE-CHEMOTHERAPEUTIC AGENT COMPLEX FOR SONODYNAMIC THERAPY SON, RNASE1, ANXA5 XDH 4495/4885LMNA 2250/4885HTT 2374/4885
US-11382987-B2 Microbubble-chemotherapeutic agent complex for sonodynamic therapy SON, RNASE1, ANXA5 XDH 4495/4885LMNA 2250/4885HTT 2374/4885
US-11970731-B2 Enhancement of nucleic acid polymerization by aromatic compounds POLN, POLB, POLRMT XDH 1496/4885LMNA 321/4885HTT 145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.