SCHEMBL2229684

SCHEMBL2229684

CCOC(=O)c1cc(=O)n(-c2ccccc2)[nH]1

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.62
GAA P10253 4/20 0.62
MEN1 O00255 2/20 0.62
KMT2A Q03164 2/20 0.62
LMNA P02545 1/20 0.62
HTT P42858 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
ALDH1A1 P00352 3/20 0.60
KDM4E B2RXH2 1/20 0.60
ALKBH5 Q6P6C2 7/20 0.55
TSHR P16473 1/20 0.52
CTSA P10619 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
POLB P06746 1/20 0.48
RAB9A P51151 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10885655 0.89 ALKBH5 (0.50) MAPTGAAMEN1KMT2ALMNA
SCHEMBL5527198 0.89 ALDH1A1 (0.60) MAPTGAAMEN1KMT2ALMNA
SCHEMBL9196875 0.88 ALDH1A1 (0.62) MAPTGAAMEN1KMT2ALMNA
SCHEMBL11426665 0.87 ALDH1A1 (0.68) MAPTGAAMEN1KMT2ALMNA
SCHEMBL8942096 0.87 TSHR (0.49) MAPTGAAMEN1KMT2ALMNA
SCHEMBL11426196 0.86 KDM4E (0.71) MAPTGAAMEN1KMT2ALMNA
SCHEMBL10755227 0.86 ALDH1A1 (0.57) MAPTGAAMEN1KMT2ALMNA
SCHEMBL1819463 0.85 ALKBH5 (0.61) MAPTGAAMEN1KMT2ALMNA
SCHEMBL10627912 0.84 TSHR (0.51) MAPTGAAMEN1KMT2ALMNA
SCHEMBL6757089 0.84 TSHR (0.51) MAPTGAAMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0988344-B1 COLORANT BLENDS CONTAINING A SALT-FORMING AZO PIGMENT AND A 1,4-DIKETO-3, 6-DIARYLPYRROLO(3,4-C)PYROLLE CIBA SC HOLDING AG (CH) 2002-01-16 EP claimed
CN-1255154-A Colorant blends containing salt-forming AZO pigment and 1,4-diketo-3,6-diaryrrolo (3,4-C) pyrolle CIBA SC HOLDING AG (CH) 2000-05-31 CN claimed
EP-0263951-B1 Disazo compounds and compositions containing them BASF LACKE & FARBEN (DE) 1994-06-15 EP claimed
EP-0485474-A1 A METHOD AND A SYSTEM FOR QUANTITATIVELY MONITORING A CHEMICAL COMPONENT DISSOLVED IN A LIQUID MEDIUM. KOEGE KEMISK VAERK (DK) 1992-05-20 EP claimed
WO-1991002254-A1 A METHOD AND A SYSTEM FOR QUANTITATIVELY MONITORING A CHEMICAL COMPONENT DISSOLVED IN A LIQUID MEDIUM KEMISK VÆRK KØGE A/S (DK) 1991-02-21 WO claimed
US-4981489-A STABILIZATION BASF LACKE & FARBEN AKTIENGESELLSCHAFT (DE) 1991-01-01 US claimed
EP-0263951-A2 Disazo compounds and compositions containing them BASF Lacke + Farben AG (DE) 1988-04-20 EP claimed
US-4496727-A ORGANIC PIGMENTS; PLASTICS; LACQUERS; INKS; COATINGS; COLOR FASTNESS CIBA-GEIGY CORPORATION (US) 1985-01-29 US claimed
US-4414151-A Chromiferous complex dyestuffs, a process for their preparation and their application P C U K PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1983-11-08 US claimed
EP-0044767-B1 CHROMIUM-COMPLEX DYESTUFFS, THEIR PREPARATION AND THEIR USE P C U K PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1983-04-06 EP claimed
US-4159264-A Automatic control of azo coupling processes in the manufacture of azo pigments CIBA-GEIGY CORPORATION (US) 1979-06-26 US claimed
JP-57049661-A None JP disclosed
US-7977570-B2 Dye-sensitized photoelectric conversion device NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2011-07-12 US disclosed
WO-2010068358-A1 INHALANT FORMULATIONS COMPRISING A BISPHOSPHONATE AND A PYRAZOLONE DERIVATIVE AND METHODS FOR USING THE SAME TEIKOKU PHARMA USA, INC. (US) 2010-06-17 WO disclosed
US-20100034752-A1 INHALANT FORMULATIONS COMPRISING A BISPHOSPHONATE AND A PYRAZOLONE DERIVATIVE AND METHODS FOR USING THE SAME TEIKOKU PHARMA USA 2010-02-11 US disclosed
US-4052374-A UNSYMMETRICAL 1:2-CHROMIUM COMPLEXES CONTAINING AN AZO COMPOUND AND AN AZOMETHINE COMPOUND BASF AKTIENGESELLSCHAFT (DT) 1977-10-04 US disclosed
US-4010151-A Water insoluble mono azo and disazo dyes containing cinnamonitrile group PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-03-01 US disclosed
US-4008213-A WATER INSOLUBLE UGINE KUHLMANN (FR) 1977-02-15 US disclosed
US-3971741-A DISPERSION PIGMENTS BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed
US-3933507-A LIGHT INSENSITIVE SILVER SALT, POLYMETHINE SENSITIZER AGFA-GEVAERT, A.G. (DT) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100034752-A1 INHALANT FORMULATIONS COMPRISING A BISPHOSPHONATE AND A PYRAZOLONE DERIVATIVE AND METHODS FOR USING THE SAME PTH1R, P2RY6, P2RY1 MAPT 4462/4885GAA 2364/4885MEN1 1403/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.