SCHEMBL1819463

SCHEMBL1819463

COC(=O)c1cc(=O)n(-c2ccccc2)[nH]1

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALKBH5 Q6P6C2 11/20 0.61
TSHR P16473 1/20 0.61
CTSA P10619 4/20 0.52
LMNA P02545 2/20 0.51
MAPT P10636 2/20 0.51
ALDH1A1 P00352 1/20 0.51
POLB P06746 1/20 0.51
BLM P54132 1/20 0.51
ATM Q13315 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MEN1 O00255 1/20 0.47
GAA P10253 1/20 0.47
HTT P42858 1/20 0.47
KMT2A Q03164 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11043171 0.89 ALKBH5 (0.55) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL11647578 0.86 ALKBH5 (0.52) ALKBH5TSHRLMNAMAPTALDH1A1
SCHEMBL2229684 0.85 MAPT (0.62) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL11093639 0.85 ALKBH5 (0.52) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL8942238 0.84 ALKBH5 (0.58) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL11441556 0.83 ALKBH5 (0.59) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL951472 0.83 ALKBH5 (0.73) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL10626579 0.83 ALKBH5 (0.56) ALKBH5TSHRCTSA
SCHEMBL10885655 0.83 ALKBH5 (0.50) ALKBH5TSHRCTSALMNAMAPT
SCHEMBL8942136 0.83 CTSA (0.57) ALKBH5TSHRCTSALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative L'OREAL S.A. 2007-06-14 US claimed
EP-1434552-A1 METHOD FOR DYEING KERATINOUS FIBRES Henkel Kommanditgesellschaft auf Aktien (DE) 2004-07-07 EP claimed
WO-2003030841-A1 METHOD FOR DYEING KERATINOUS FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2003-04-17 WO claimed
US-4496727-A ORGANIC PIGMENTS; PLASTICS; LACQUERS; INKS; COATINGS; COLOR FASTNESS CIBA-GEIGY CORPORATION (US) 1985-01-29 US claimed
EP-3885340-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2024-11-27 EP disclosed
EP-3885340-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2021-09-29 EP disclosed
US-11046713-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2021-06-29 US disclosed
EP-3369732-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2021-05-26 EP disclosed
US-20200299307-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2020-09-24 US disclosed
US-10711013-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2020-07-14 US disclosed
US-20190100536-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2019-04-04 US disclosed
US-10118933-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2018-11-06 US disclosed
US-4322529-A Tertiary-alkylamine salts of azine dyestuffs CIBA-GEIGY CORPORATION (US) 1982-03-30 US disclosed
US-4246410-A BENZINDOLE DYES OF YELLOW AND RED CIBA -GEIGY AKTIENGESELLSCHAFT (CH) 1981-01-20 US disclosed
US-4225492-A Water-soluble disazo dyestuffs, prepared from unsymmetrical heterocyclic diamines CASSELLA AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4189427-A Azo dyestuffs from benzene diazo component fused to an aliphatic ring and containing two cyano substituents ortho to the azo group BAYER AKTIENGESELLSCHAFT (DE) 1980-02-19 US disclosed
US-4139343-A PYRAZOLONE DYES, FOR NYLONG, POLYESTERS, ACRYLICS CROMPTON & KNOWLES CORPORATION (US) 1979-02-13 US disclosed
US-4089078-A Arylazopyrazolone dyes for polyester AMERICAN COLOR & CHEMICAL CORPORATION (US) 1978-05-16 US disclosed
US-4082741-A FASTNESS TO HEAT, LIGHT, MIGRATION, CHEMICALS HOECHST AKTIENGESELLSCHAFT (DT) 1978-04-04 US disclosed
US-3994872-A SOLUBILITY CIBA-GEIGY CORPORATION (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative KRT18, NDUFB5, NDUFB7 ALKBH5 321/4885TSHR 4878/4885CTSA 4860/4885
US-10118933-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG ALKBH5 2772/4885TSHR 301/4885CTSA 3936/4885
US-10711013-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG ALKBH5 2772/4885TSHR 301/4885CTSA 3936/4885
US-20200299307-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG ALKBH5 2772/4885TSHR 301/4885CTSA 3936/4885
US-20190100536-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG ALKBH5 2772/4885TSHR 301/4885CTSA 3936/4885
US-11046713-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG ALKBH5 2772/4885TSHR 301/4885CTSA 3936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.