SCHEMBL2229772

SCHEMBL2229772

C=C(C)C(=O)OCCC[Si](C)(OCc1ccccc1)OCc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 0.44
POLB P06746 2/20 0.44
HTT P42858 2/20 0.44
APEX1 P27695 1/20 0.44
ALDH1A1 P00352 4/20 0.43
TSHR P16473 3/20 0.41
MAPK1 P28482 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
CYP3A4 P08684 1/20 0.40
LMNA P02545 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ATM Q13315 1/20 0.37
KMT2A Q03164 2/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A3 Q01959 1/20 0.36
THRB P10828 1/20 0.36
NAAA Q02083 1/20 0.35
MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15367093 0.95 TDP1 (0.41) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL3129906 0.90 TDP1 (0.44) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL1067126 0.82 THRB (0.47) TDP1ALDH1A1TSHRMAPK1L3MBTL1
SCHEMBL230550 0.81 TDP1 (0.49) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL15369481 0.80 LMNA (0.42) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL316676 0.79 NAAA (0.49) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL6384289 0.79 TDP1 (0.52) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL1537191 0.78 HCAR2 (0.44) TDP1POLBALDH1A1TSHRMAPK1
SCHEMBL26282469 0.78 TDP1 (0.48) TDP1POLBHTTAPEX1ALDH1A1
SCHEMBL3101732 0.78 TDP1 (0.48) TDP1POLBHTTAPEX1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1298166-B1 RUBBER COMPOSITION JSR CORP (JP) 2007-02-21 EP claimed
US-6699935-B2 A CROSSLINKED RUBBER PARTICLES CONTAINING CONJUGATED DIENE MONOMER, AROMATIC VINYL MONOMER AND MONOMER WITH AT LEAST TWO POLYMERIZABLE UNSATURATED GROUPS DISPERSED IN A CONJUGATED DIENE/AROMATIC VINYL COPOLYMER; RESIST TO ROLLING, SKID, WEAR JSR CORPORATION (JP) 2004-03-02 US claimed
US-6653404-B2 Melt processability; dimensional stability JSR CORPORATION (JP) 2003-11-25 US claimed
US-20030125467-A1 A crosslinked rubber particles containing conjugated diene monomer, aromatic vinyl monomer and monomer with at least two polymerizable unsaturated groups dispersed in a conjugated diene/aromatic vinyl copolymer; resist to rolling, skid, wear JSR CORPORATION (JP) 2003-07-03 US claimed
EP-1298166-A1 RUBBER COMPOSITION JSR Corporation (JP) 2003-04-02 EP claimed
US-20010053813-A1 Rubber compositions JSR CORPORATION (JP) 2001-12-20 US claimed
EP-4349902-A1 RUBBER COMPOSITION AND TIRE BRIDGESTONE CORPORATION (JP) 2024-04-10 EP disclosed
WO-2022254751-A1 RUBBER COMPOSITION AND TIRE 株式会社ブリヂストン 2022-12-08 WO disclosed
EP-3851489-A1 MODIFIED MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, RESIN COMPOSITION, TIRE AND RESIN PRODUCT BRIDGESTONE CORPORATION (JP) 2021-07-21 EP disclosed
EP-3730547-A1 RUBBER COMPOSITION Bridgestone Corporation (JP) 2020-10-28 EP disclosed
EP-3725836-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Bridgestone Corporation (JP) 2020-10-21 EP disclosed
CN-108602987-B Rubber composition and tire 株式会社普利司通 2020-07-21 CN disclosed
US-20180244808-A1 METHOD FOR PRODUCING MODIFIED DIENE-BASED RUBBER, RUBBER COMPOSITION AND TIRE BRIDGESTONE CORPORATION (JP) 2018-08-30 US disclosed
US-20020045691-A1 Conjugated diene-based rubber, oil extended rubber and rubber composition containing the same JSR CORPORATION (JP) 2002-04-18 US disclosed
EP-1184415-A2 Conjugated diene-based rubber, oil extended rubber and rubber composition containing the same JSR Corporation (JP) 2002-03-06 EP disclosed
US-20020007011-A1 Crosslinked rubber particles and rubber compositions JSR CORPORATION (JP) 2002-01-17 US disclosed
US-20010053813-A1 Rubber compositions JSR CORPORATION (JP) 2001-12-20 US disclosed
EP-1152030-A2 Rubber mixtures based on crosslinked rubber particles and non-crosslinked rubbers JSR Corporation (JP) 2001-11-07 EP disclosed
EP-1149866-A2 Rubber mixtures based on crosslinked rubber particles and non-crosslinked rubbers JSR Corporation (JP) 2001-10-31 EP disclosed
EP-1149867-A2 Crosslinked rubber particles and rubber compositions JSR Corporation (JP) 2001-10-31 EP disclosed