SCHEMBL230550

SCHEMBL230550

C=C(C)C(=O)OCCC[Si](C)(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.49
POLB P06746 1/20 0.49
APEX1 P27695 1/20 0.49
HTT P42858 1/20 0.49
TSHR P16473 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.39
ELANE P08246 1/20 0.38
THRB P10828 2/20 0.37
MTNR1A P48039 2/20 0.37
MTNR1B P49286 2/20 0.37
RECQL P46063 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
NPC1 O15118 1/20 0.33
GAA P10253 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8899918 0.89 TDP1 (0.49) TDP1POLBAPEX1HTTTSHR
SCHEMBL229200 0.89 TDP1 (0.49) TDP1POLBAPEX1HTTTSHR
SCHEMBL7617869 0.89 TDP1 (0.40) TDP1POLBAPEX1HTTTSHR
SCHEMBL230778 0.87 TDP1 (0.50) TDP1POLBAPEX1HTTTSHR
SCHEMBL8899641 0.87 TDP1 (0.50) TDP1POLBAPEX1HTTTSHR
SCHEMBL2167795 0.84 TDP1 (0.47) TDP1POLBAPEX1HTTTSHR
SCHEMBL2166946 0.84 TDP1 (0.47) TDP1POLBAPEX1HTTTSHR
SCHEMBL230455 0.82 ELANE (0.42) TDP1POLBAPEX1HTTTSHR
SCHEMBL2229772 0.81 TDP1 (0.44) TDP1POLBAPEX1HTTTSHR
SCHEMBL230344 0.81 THRB (0.56) TDP1TSHRL3MBTL1THRBMTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7750087-B2 Modified polymers prepared with lanthanide-based catalysts BRIDGESTONE CORPORATION (JP) 2010-07-06 US claimed
EP-1298166-B1 RUBBER COMPOSITION JSR CORP (JP) 2007-02-21 EP claimed
US-20060030677-A1 Prepared by polymerizing conjugated monomer with a lanthanide-based catalyst to form a pseudo-living polymer and reacting the polymer with a di- or trihydrocarbyloxysilane having a reactive functional group such as (meth)acrylate, epoxy, or isocyanate that forms a chemical bond with the polymer; curable ENEOS MATERIALS CORPORATION (JP) 2006-02-09 US claimed
US-6992147-B1 Modified polymers prepared with lanthanide-based catalysts BRIDGESTONE CORPORATION (JP) 2006-01-31 US claimed
US-6699935-B2 A CROSSLINKED RUBBER PARTICLES CONTAINING CONJUGATED DIENE MONOMER, AROMATIC VINYL MONOMER AND MONOMER WITH AT LEAST TWO POLYMERIZABLE UNSATURATED GROUPS DISPERSED IN A CONJUGATED DIENE/AROMATIC VINYL COPOLYMER; RESIST TO ROLLING, SKID, WEAR JSR CORPORATION (JP) 2004-03-02 US claimed
US-6653404-B2 Melt processability; dimensional stability JSR CORPORATION (JP) 2003-11-25 US claimed
EP-1298166-A1 RUBBER COMPOSITION JSR Corporation (JP) 2003-04-02 EP claimed
US-20010053813-A1 Rubber compositions JSR CORPORATION (JP) 2001-12-20 US claimed
EP-4349902-A1 RUBBER COMPOSITION AND TIRE BRIDGESTONE CORPORATION (JP) 2024-04-10 EP disclosed
EP-3851489-A1 MODIFIED MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, RESIN COMPOSITION, TIRE AND RESIN PRODUCT BRIDGESTONE CORPORATION (JP) 2021-07-21 EP disclosed
EP-3730547-A1 RUBBER COMPOSITION Bridgestone Corporation (JP) 2020-10-28 EP disclosed
EP-3725836-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Bridgestone Corporation (JP) 2020-10-21 EP disclosed
US-20180244808-A1 METHOD FOR PRODUCING MODIFIED DIENE-BASED RUBBER, RUBBER COMPOSITION AND TIRE BRIDGESTONE CORPORATION (JP) 2018-08-30 US disclosed
EP-3345933-A1 METHOD FOR PRODUCING MODIFIED DIENE RUBBER, RUBBER COMPOSITION, AND TIRE Bridgestone Corporation (JP) 2018-07-11 EP disclosed
US-20020007011-A1 Crosslinked rubber particles and rubber compositions JSR CORPORATION (JP) 2002-01-17 US disclosed
US-20010053813-A1 Rubber compositions JSR CORPORATION (JP) 2001-12-20 US disclosed
EP-1152030-A2 Rubber mixtures based on crosslinked rubber particles and non-crosslinked rubbers JSR Corporation (JP) 2001-11-07 EP disclosed
EP-1149866-A2 Rubber mixtures based on crosslinked rubber particles and non-crosslinked rubbers JSR Corporation (JP) 2001-10-31 EP disclosed
EP-1149867-A2 Crosslinked rubber particles and rubber compositions JSR Corporation (JP) 2001-10-31 EP disclosed
US-5700874-A CONJUGATED DIENE/VINYLAROMATIC HYDROCARBON COPOLYMER MODIFIED WITH ALKOXYSILANE BRIDGESTONE CORPORATION (JP) 1997-12-23 US disclosed