Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4305734 | 0.88 | LMNA (0.43) | TAS1R3TAS1R1TAS1R2LMNAPOLB | |
| SCHEMBL21180476 | 0.87 | CHRNA1 (0.43) | TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL12497673 | 0.83 | EGFR (0.48) | TAS1R3TAS1R1TAS1R2LMNAKCNQ3 | |
| SCHEMBL19655646 | 0.80 | PTPN1 (0.49) | LMNACACNA1HCACNA1BCACNA1CHDAC8 | |
| SCHEMBL5955544 | 0.79 | PLOD2 (0.46) | LMNAPOLB | |
| SCHEMBL2063004 | 0.79 | EPHX2 (0.57) | — | |
| SCHEMBL311109 | 0.78 | EPHX2 (0.43) | TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL30208027 | 0.78 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL8558279 | 0.77 | CA12 (0.46) | POLB | |
| SCHEMBL14830379 | 0.76 | ALDH1A1 (0.52) | LMNAPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157194-A1 | 1,2,4-TRIAZIN-3(2H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |