SCHEMBL2230625

SCHEMBL2230625

CCCC(=O)OCOC(=O)NC(CCC(=O)O)c1ccc(Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.40
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4755055 0.92 UTS2R (0.42) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL637958 0.90 EPHX2 (0.43) UTS2RLMNASMN1; SMN2
SCHEMBL638108 0.88 LMNA (0.37) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL2231738 0.88 UTS2R (0.42) UTS2R
SCHEMBL917102 0.87 CCKBR (0.49) UTS2RHTT
SCHEMBL2233808 0.87 UTS2R (0.41) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL2231120 0.86 UTS2R (0.40) UTS2R
SCHEMBL1884159 0.85 SMN1; SMN2 (0.37) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL6684836 0.84 SMN1; SMN2 (0.48) UTS2RSMN1; SMN2
SCHEMBL2231578 0.84 UTS2R (0.39) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9944592-B2 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use XENOPORT, INC. (US) 2018-04-17 US disclosed
US-20170190657-A1 ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE XENOPORT, INC. (US) 2017-07-06 US disclosed
EP-2354120-A1 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XenoPort, Inc. (US) 2011-08-10 EP disclosed
US-20090234138-A1 ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS XENOPORT, INC. 2009-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170190657-A1 ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE APEH, ABAT, SI UTS2R 1572/4885LMNA 3875/4885HTT 1739/4885
US-20090234138-A1 ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS APEH, ABAT, GABARAPL1 UTS2R 1377/4885LMNA 3907/4885HTT 1443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.