Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 4/20 | 0.53 |
| ▸ | KDM1A | O60341 | 11/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31495099 | 0.85 | KDM1A (0.62) | EP300KDM1AMAOBSLC6A2SLC6A4 | |
| SCHEMBL22309754 | 0.85 | MET (0.58) | MAOBMETNQO2AKT1 | |
| SCHEMBL21322016 | 0.82 | EP300 (0.47) | EP300KDM1AMAOBSLC6A2SLC6A4 | |
| SCHEMBL24081472 | 0.79 | MET (0.47) | METNQO2 | |
| SCHEMBL30905863 | 0.78 | MET (0.55) | EP300KDM1AMAOBMETNQO2 | |
| SCHEMBL21322013 | 0.77 | MET (0.49) | EP300KDM1AMAOBSLC6A2SLC6A4 | |
| SCHEMBL2454661 | 0.76 | MET (0.42) | EP300KDM1AMAOBMETNQO2 | |
| SCHEMBL22310407 | 0.76 | CCNA2 (0.46) | EP300METNQO2 | |
| SCHEMBL12241143 | 0.75 | MET (0.44) | EP300KDM1AMAOBMETNQO2 | |
| SCHEMBL21322269 | 0.75 | MET (0.44) | EP300KDM1AMAOBMETNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3919492-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | Medshine Discovery Inc. (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020156453-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | 南京明德新药研发有限公司 | 2020-08-06 | — | — | WO | disclosed |