Sugi Predict

Sugi Predict / Compounds / SCHEMBL363365

SCHEMBL363365

SCHEMBL363365

O=C(O)c1cc(Cl)c(F)cc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.48
▸ NFE2L2 Q16236 1/20 0.48
▸ KDM4E B2RXH2 2/20 0.44
▸ ASPH Q12797 1/20 0.44
▸ KDM8 Q8N371 1/20 0.44
▸ ALDH1A1 P00352 3/20 0.43
▸ TSHR P16473 3/20 0.43
▸ TP53 P04637 1/20 0.43
▸ CASP1 P29466 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ AKR1C4 P17516 1/20 0.42
▸ AKR1C3 P42330 1/20 0.42
▸ AKR1C2 P52895 1/20 0.42
▸ AKR1C1 Q04828 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ PKM P14618 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ HTT P42858 1/20 0.41
▸ KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29488312 1.00 KEAP1 (0.48) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL223134 0.91 KEAP1 (0.53) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL31586627 0.88 KEAP1 (0.55) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL14331830 0.88 KEAP1 (0.50) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL364382 0.86 KEAP1 (0.48) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL5872835 0.83 KDM4E (0.52) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL18013115 0.83 KEAP1 (0.46) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL27617055 0.83 KEAP1 (0.50) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL5511191 0.83 PYGL (0.50) KEAP1NFE2L2KDM4EALDH1A1TSHR
SCHEMBL6657490 0.82 KEAP1 (0.46) KEAP1NFE2L2KDM4EASPHKDM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240376100-A1 PAPD5 AND/OR PAPD7 INHIBITING 4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID DERIVATIVES Redona Therapeutics, Inc. 2024-11-14 — — US disclosed
US-20240254136-A1 COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS Redona Therapeutics, Inc. 2024-08-01 — — US disclosed
EP-4399206-A1 PAPD5 AND/OR PAPD7 INHIBITING 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID DERIVATIVES Redona Therapeutics, Inc. (US) 2024-07-17 — — EP disclosed
CN-118201914-A 4-Oxo-1, 4-dihydroquinoline-3-carboxylic acid derivatives as PAPD5 and/or PAPD7 inhibitors 雷多纳治疗公司 2024-06-14 — — CN disclosed
US-11834391-B2 Pantothenamide analogues MMV MEDICINES FOR MALARIA VENTURE (CH) 2023-12-05 — — US disclosed
US-11834391-B2 Pantothenamide analogues MMV MEDICINES FOR MALARIA VENTURE (CH) 2023-12-05 — — US disclosed
US-11834391-B2 Pantothenamide analogues MMV MEDICINES FOR MALARIA VENTURE (CH) 2023-12-05 — — US disclosed
CN-113286778-B Ubiquitin analogs MMV疟疾药物投资公司 2023-09-22 — — CN disclosed
US-11730720-B2 ALK5 inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-08-22 — — US disclosed
US-11730720-B2 ALK5 inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-08-22 — — US disclosed
CN-103044397-A New method for synthesizing besifloxacin FARMASINO PHARMACEUTICALS ANHUI CO LTD 2013-04-17 — — CN disclosed
WO-2012007861-A1 N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS PFIZER LIMITED (GB) 2012-01-19 — — WO disclosed
WO-2012007883-A1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LIMITED (GB) 2012-01-19 — — WO disclosed
US-20120010183-A1 Chemical Compounds PFIZER LIMITED (GB) 2012-01-12 — — US disclosed
US-20120010207-A1 Chemical Compounds PFIZER LIMITED (GB) 2012-01-12 — — US disclosed
US-20070072831-A1 Integrase inhibitor compounds GILEAD SCIENCES, INC. 2007-03-29 — — US disclosed
US-20070072831-A1 Integrase inhibitor compounds GILEAD SCIENCES, INC. 2007-03-29 — — US disclosed
EP-0894784-B1 4-FLUOROSALICYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME IHARA CHEMICAL IND CO (JP) 2003-01-08 — — EP disclosed
US-6166246-A 4-fluorosalicyclic acid derivative and process for production thereof IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2000-12-26 — — US disclosed
EP-0894784-A1 4-FLUOROSALICYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 1999-02-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010207-A1 Chemical Compounds SCN1A, SCN1B, SCN7A KEAP1 1810/4885NFE2L2 3855/4885KDM4E 3006/4885
US-20070072831-A1 Integrase inhibitor compounds TYMP, CDKN1A, PAICS KEAP1 3953/4885NFE2L2 4315/4885KDM4E 1723/4885
US-20120010183-A1 Chemical Compounds SCN1A, SCN1B, SCN7A KEAP1 1442/4885NFE2L2 3072/4885KDM4E 3227/4885
US-11730720-B2 ALK5 inhibitors ALK, ACVR1, ACVRL1 KEAP1 4571/4885NFE2L2 4760/4885KDM4E 997/4885
US-11834391-B2 Pantothenamide analogues NAMPT, VKORC1, NME4 KEAP1 376/4885NFE2L2 2107/4885KDM4E 1993/4885
US-20240376100-A1 PAPD5 AND/OR PAPD7 INHIBITING 4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID DERIVATIVES PAPSS1, OTUD7B, BRD7 KEAP1 1909/4885NFE2L2 3341/4885KDM4E 2402/4885
US-20240254136-A1 COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS NSUN3, NSUN2, RBM3 KEAP1 1639/4885NFE2L2 2985/4885KDM4E 1121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.