Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340392 | 0.99 | KDM4E (0.35) | KDM4EPOLBCYP2D6TSHRHSD17B10 | |
| SCHEMBL22340393 | 0.91 | LTB4R (0.33) | — | |
| Hydrochloric Acid SCHEMBL22322860 | 0.88 | ACHE (0.32) | KDM4ENPC1GAAMAPTHPGD | |
| SCHEMBL22322834 | 0.86 | CYP11B2 (0.32) | TERT | |
| SCHEMBL22340811 | 0.86 | NPC1 (0.32) | KDM4ENPC1GAAMAPTHPGD | |
| SCHEMBL22340380 | 0.85 | LTB4R (0.34) | KDM4ECYP2D6TSHRHSD17B10TERT | |
| SCHEMBL22340379 | 0.82 | ALDH1A1 (0.51) | KDM4EHSD17B10GAAMAPTL3MBTL1 | |
| SCHEMBL22322859 | 0.80 | ALDH1A1 (0.31) | KDM4EGAAMAPTHPGDL3MBTL1 | |
| SCHEMBL22340705 | 0.77 | ALDH1A1 (0.38) | KDM4ECYP2D6TSHRHSD17B10NPC1 | |
| SCHEMBL22322810 | 0.76 | KDM4E (0.34) | KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020161162-A1 | HERBICIDAL PYRIDINIUM COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2020-08-13 | — | — | WO | disclosed |