Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 2/20 | 0.35 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509324 | 1.00 | LRRK2 (0.41) | LRRK2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL28686553 | 0.86 | LMNA (0.50) | LMNASMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL29509339 | 0.86 | LMNA (0.50) | LMNASMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL22323782 | 0.85 | LRRK2 (0.47) | LRRK2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL22323632 | 0.78 | LRRK2 (0.37) | LRRK2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL29381363 | 0.78 | LRRK2 (0.37) | LRRK2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL29380889 | 0.77 | OXTR (0.51) | LMNATP53OXTRALDH1A1HPGD | |
| SCHEMBL15005979 | 0.73 | LRRK2 (0.47) | LRRK2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL22324030 | 0.71 | LRRK2 (0.38) | LRRK2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL19147152 | 0.70 | GPR35 (0.41) | SMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3920917-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163248-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |