SCHEMBL22326112

SCHEMBL22326112

Cc1cc(C(c2cc(C)c(N)cc2C)C(F)(F)F)c(C)cc1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.46
TSHR P16473 2/20 0.46
MAPK1 P28482 1/20 0.46
ALDH1A1 P00352 5/20 0.39
GAA P10253 2/20 0.35
POLB P06746 1/20 0.35
GFER P55789 1/20 0.35
CYP1A2 P05177 1/20 0.34
ALOX15 P16050 1/20 0.34
CASP7 P55210 1/20 0.34
HIF1A Q16665 1/20 0.34
HSD17B10 Q99714 1/20 0.34
AR P10275 2/20 0.33
TERT O14746 1/20 0.33
TDP1 Q9NUW8 2/20 0.32
CASP1 P29466 1/20 0.32
CD44 P16070 1/20 0.32
PKM P14618 1/20 0.31
ATAD2 Q6PL18 1/20 0.31
UHRF1 Q96T88 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22336948 0.82 ESR1 (0.31) CYP3A4TSHRMAPK1ESR1ESR2
SCHEMBL24191002 0.80 ALDH1A1 (0.36) CYP3A4TSHRMAPK1ALDH1A1GAA
SCHEMBL30429291 0.80 ALDH1A1 (0.36) CYP3A4TSHRMAPK1ALDH1A1GAA
SCHEMBL25207189 0.77 SMN1; SMN2 (0.50) TSHRMAPK1ALDH1A1GAAPOLB
SCHEMBL22326131 0.77 ALOX15 (0.44) CYP3A4TSHRMAPK1ALDH1A1GAA
SCHEMBL31694457 0.77 ALOX15 (0.44) CYP3A4TSHRMAPK1ALDH1A1GAA
SCHEMBL26327919 0.76 SMN1; SMN2 (0.35) ALOX15AR
SCHEMBL22326113 0.73 PDE10A (0.47) CYP3A4TSHRMAPK1ALDH1A1GAA
SCHEMBL19840416 0.73 CYP3A4 (0.55) CYP3A4TSHRMAPK1ALDH1A1GAA
SCHEMBL15695593 0.71 TSHR (0.52) CYP3A4TSHRMAPK1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US claimed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO claimed
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2025-10-07 US disclosed
US-12351685-B2 Polyamide acid, polyimide, optical film, display device and production methods thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2025-07-08 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
WO-2023182141-A1 EPOXY COMPOUND, EPOXY RESIN, EPOXY RESIN COMPOSITION, CURED PRODUCT, PREPREG, FIBER-REINFORCED COMPOSITE MATERIAL, PRODUCING METHODS THEREFOR, SEALING MATERIAL, SEMICONDUCTOR DEVICE, METHOD FOR SEALING SEMICONDUCTOR ELEMENT, AND METHOD FOR USING SAME AS SEALING MATERIAL セントラル硝子株式会社 2023-09-28 WO disclosed
EP-4163319-A1 POLYAMIDE, POLYAMIDE-IMIDE, DERIVATIVES OF THESE, OPTICAL FILM, DISPLAY DEVICE, AND PRODUCTION METHODS THEREFOR Central Glass Company, Limited (JP) 2023-04-12 EP disclosed
US-20220119595-A1 Polyamide Acid, Polyimide, Optical Film, Display Device and Production Methods Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-21 US disclosed
US-20220119595-A1 Polyamide Acid, Polyimide, Optical Film, Display Device and Production Methods Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-21 US disclosed
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US disclosed
WO-2020162411-A1 POLYAMIDE ACID, POLYIMIDE, OPTICAL FILM, DISPLAY DEVICE AND PRODUCTION METHODS OF THOSE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane NAF1, FXR1, AFF1 CYP3A4 1051/4885TSHR 1232/4885MAPK1 1224/4885
US-12351685-B2 Polyamide acid, polyimide, optical film, display device and production methods thereof PUF60, PARG, TET3 CYP3A4 4134/4885TSHR 3460/4885MAPK1 3057/4885
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane NAF1, FXR1, AFF1 CYP3A4 1051/4885TSHR 1232/4885MAPK1 1224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.