SCHEMBL22326134

SCHEMBL22326134

Oc1ccc(C(c2ccc(O)c(F)c2)C(F)(F)F)cc1F

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.52
ESR2 Q92731 3/20 0.52
SHBG P04278 1/20 0.50
HSD17B1 P14061 5/20 0.39
HSD17B2 P37059 5/20 0.39
NR3C1 P04150 4/20 0.39
PGR P06401 2/20 0.39
AR P10275 2/20 0.39
CYP17A1 P05093 1/20 0.38
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
GRIN2B Q13224 1/20 0.35
MGLL Q99685 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13885099 0.83 SHBG (0.47) ESR1ESR2SHBGHSD17B1HSD17B2
SCHEMBL4471795 0.79 SHBG (0.55) ESR1ESR2SHBGHSD17B1HSD17B2
SCHEMBL30343458 0.79 SHBG (0.55) ESR1ESR2SHBGHSD17B1HSD17B2
SCHEMBL1597362 0.79 SHBG (0.55) ESR1ESR2SHBGHSD17B1HSD17B2
SCHEMBL27272818 0.78 SHBG (0.40) SHBGNR3C1PGRARLMNA
SCHEMBL8816389 0.77 SHBG (0.53) ESR1ESR2SHBGHSD17B1HSD17B2
SCHEMBL1596219 0.77 SHBG (0.53) ESR1ESR2SHBGHSD17B1HSD17B2
SCHEMBL22326111 0.77 ALDH1A1 (0.46) ESR1ESR2SHBG
SCHEMBL22326126 0.77 ESR1 (0.50) ESR1ESR2HSD17B1HSD17B2LMNA
SCHEMBL11050693 0.77 ESR1 (0.50) ESR1ESR2NR3C1PGRAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO claimed
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2025-10-07 US disclosed
US-12098238-B2 Curable resin, curable resin composition, cured product, electronic device, laminated board material, electronic component encapsulant, and method for producing curable resin CENTRAL GLASS COMPANY, LIMITED (JP) 2024-09-24 US disclosed
EP-4089131-B1 CURABLE RESIN, CURABLE RESIN COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, LAMINATED BOARD MATERIAL, ELECTRONIC COMPONENT ENCAPSULANT, AND METHOD FOR PRODUCING CURABLE RESIN CENTRAL GLASS CO LTD (JP) 2024-06-26 EP disclosed
US-20230097638-A1 Curable Resin, Curable Resin Composition, Cured Product, Electronic Device, Laminated Board Material, Electronic Component Encapsulant, and Method for Producing Curable Resin CENTRAL GLASS COMPANY, LIMITED (JP) 2023-03-30 US disclosed
EP-4089131-A1 CURABLE RESIN, CURABLE RESIN COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, LAMINATED BOARD MATERIAL, ELECTRONIC COMPONENT ENCAPSULANT, AND METHOD FOR PRODUCING CURABLE RESIN Central Glass Company, Limited (JP) 2022-11-16 EP disclosed
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane NAF1, FXR1, AFF1 ESR1 4737/4885ESR2 3744/4885SHBG 3564/4885
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane NAF1, FXR1, AFF1 ESR1 4737/4885ESR2 3744/4885SHBG 3564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.