Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029757 | 0.85 | MAPK8 (0.52) | MAPK8NR3C2MAOBPARP10TAAR1 | |
| SCHEMBL6864466 | 0.85 | TAAR1 (0.50) | MAPK8MAOBPARP10VNN1TAAR1 | |
| SCHEMBL27814786 | 0.84 | FFAR1 (0.49) | MAPK8VNN1SLC1A1RAB9AMEN1 | |
| SCHEMBL2209416 | 0.83 | VNN1 (0.49) | MAPK8MAOBVNN1TAAR1RAB9A | |
| Hydrochloric Acid SCHEMBL1150988 | 0.81 | TAAR1 (0.52) | MAPK8MAOBPARP10VNN1TAAR1 | |
| SCHEMBL11178482 | 0.80 | SRC (0.55) | VNN1SLC1A1RAB9AMEN1KMT2A | |
| SCHEMBL8053109 | 0.80 | VNN1 (0.49) | MAPK8MAOBPARP10VNN1TAAR1 | |
| SCHEMBL13237150 | 0.80 | VNN1 (0.47) | MAPK8MAOBVNN1TAAR1RAB9A | |
| SCHEMBL28434907 | 0.80 | CES1 (0.47) | MAPK8VNN1RAB9AMEN1NPC1 | |
| SCHEMBL3371173 | 0.79 | VNN1 (0.45) | MAPK8VNN1TAAR1SLC1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | OPRK1, OPRD1, OPRL1 | MAPK8 1622/4885NR3C2 47/4885MAOB 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.