Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTPRG | P23470 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28345653 | 0.89 | TSHR (0.41) | PTPN2PTPN1PTPRCGRIK1AXL | |
| SCHEMBL21356996 | 0.85 | BCAT2 (0.44) | HMGB1LMNAKMT2AHTR7BCAT2 | |
| SCHEMBL4732259 | 0.84 | PTPN2 (0.43) | PTPN2PTPN1PTPRCGRIK1AXL | |
| SCHEMBL4196235 | 0.82 | PTPN1 (0.42) | PTPN2PTPN1PTPRCGRIK1AXL | |
| SCHEMBL6632299 | 0.81 | PTPN2 (0.41) | PTPN2PTPN1PTPRCGRIK1AXL | |
| SCHEMBL10889896 | 0.81 | LMNA (0.47) | PTPN2PTPN1PTPRCAXLLMNA | |
| SCHEMBL5323308 | 0.79 | LTB4R (0.41) | PTPN2PTPN1PTPRCGRIK1AXL | |
| SCHEMBL27675976 | 0.78 | GPR35 (0.49) | AXLLMNAABCC1GPR35 | |
| SCHEMBL2065269 | 0.78 | ABCC1 (0.50) | PTPN2PTPN1PTPRCAXLLMNA | |
| SCHEMBL1401564 | 0.78 | GPR35 (0.44) | PTPN2PTPN1PTPRCGRIK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528908-A1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | Allergan, Inc. (US) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011094231-A1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2011-08-04 | — | — | WO | disclosed |