Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FOS | P01100 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22330510 | 0.85 | DHODH (0.43) | DHODHALDH1A1HIF1ATRPV1PTGER1 | |
| SCHEMBL18562815 | 0.74 | HPGD (0.51) | ALDH1A1MAPT | |
| SCHEMBL26725046 | 0.74 | L3MBTL1 (0.64) | ALDH1A1HIF1AL3MBTL1MAPTPKM | |
| SCHEMBL22916183 | 0.73 | ALDH1A1 (0.55) | ALDH1A1HIF1APTGER1L3MBTL1MAPT | |
| SCHEMBL17039801 | 0.73 | LMNA (0.52) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17039776 | 0.72 | LMNA (0.50) | ALDH1A1L3MBTL1TSHRHTT | |
| SCHEMBL18562793 | 0.71 | MAPK1 (0.44) | ALDH1A1HTT | |
| SCHEMBL11620358 | 0.71 | KDM4E (0.55) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL2355180 | 0.68 | ADRB2 (0.44) | MEN1KMT2ATSHR | |
| SCHEMBL3583816 | 0.67 | XDH (0.66) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107899-B1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE 2 (ALDH2) BINDING POLYCYCLIC AMIDES AND THEIR USE FOR THE TREATMENT OF CANCER | AVIV THERAPEUTICS INC (US) | 2020-08-12 | — | — | EP | disclosed |