Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560718 | 0.84 | GABRA1 (0.42) | CYP2D6GABRA1GABRB2EGFRMGLL | |
| SCHEMBL198461 | 0.83 | CSNK2A2 (0.52) | CSNK2A2CSNK2BCSNK2A1CSNK2A3CYP2D6 | |
| SCHEMBL2776956 | 0.81 | CSNK2A2 (0.50) | CSNK2A2CSNK2BCSNK2A1CSNK2A3CYP2D6 | |
| Ethane SCHEMBL3687850 | 0.81 | CSNK2A2 (0.50) | CSNK2A2CSNK2BCSNK2A1CSNK2A3CYP2D6 | |
| SCHEMBL11382359 | 0.81 | CSNK2A2 (0.50) | CSNK2A2CSNK2BCSNK2A1CSNK2A3CYP2D6 | |
| SCHEMBL22342192 | 0.81 | FFAR1 (0.40) | ALOX5APFEN1EGFRLMNANPC1 | |
| SCHEMBL15912540 | 0.79 | MAPK1 (0.42) | CYP2D6ALOX5APFEN1EGFRLMNA | |
| SCHEMBL2208060 | 0.78 | DPP4 (0.54) | ALOX5APFEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL3083039 | 0.78 | MAPT (0.39) | CYP2D6GABRA1GABRB2ALOX5APFEN1 | |
| SCHEMBL24042759 | 0.77 | KDM4E (0.44) | CSNK2A2CSNK2BCSNK2A1CSNK2A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255478-A1 | NOVEL COMPOUNDS ACTIVATING THE NRF2 PATHWAY | ALMIRALL SA (ES) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255478-A1 | NOVEL COMPOUNDS ACTIVATING THE NRF2 PATHWAY | KEAP1, NFE2L2, HMOX1 | CSNK2A2 2092/4885CSNK2B 2210/4885CSNK2A1 2174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.