Methylene Chloride

Methylene Chloride

SCHEMBL22344179

ClCCl.Clc1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.61
LMNA P02545 2/20 0.57
CYP2A6 P11509 1/20 0.57
AHR P35869 2/20 0.52
MAOB P27338 1/20 0.50
ALOX5 P09917 1/20 0.48
IDO1 P14902 2/20 0.43
GSK3B P49841 1/20 0.42
GFER P55789 1/20 0.41
KIF11 P52732 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
LSS P48449 1/20 0.40
SLC6A2 P23975 1/20 0.40
HTR2A P28223 1/20 0.40
SLC6A4 P31645 1/20 0.40
HRH1 P35367 1/20 0.40
HTR2B P41595 1/20 0.40
CHRNA4 P43681 1/20 0.40
SLC6A3 Q01959 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3952742 0.89 CYP1A2 (0.73) CYP1A2LMNACYP2A6AHRMAOB
SCHEMBL28215 0.89 CYP1A2 (0.73) CYP1A2LMNACYP2A6AHRMAOB
SCHEMBL11165087 0.89 CYP1A2 (0.73) CYP1A2LMNACYP2A6AHRMAOB
1,4-Dichlorobenzene SCHEMBL28108447 0.89 LMNA (0.73) CYP1A2LMNACYP2A6IDO1GSK3B
SCHEMBL25437316 0.85 CYP1A2 (0.69) CYP1A2LMNACYP2A6AHRMAOB
Hydrogen Sulfide SCHEMBL10394839 0.85 CYP1A2 (0.69) CYP1A2LMNACYP2A6AHRMAOB
SCHEMBL2069301 0.82 MAOB (0.54) CYP1A2LMNACYP2A6AHRMAOB
Ethyne SCHEMBL29216096 0.81 CYP1A2 (0.65) CYP1A2LMNACYP2A6AHRMAOB
SCHEMBL9160072 0.79 AHR (0.68) CYP1A2LMNACYP2A6AHRMAOB
Methyl Alcohol SCHEMBL28374011 0.79 CYP1A2 (0.61) CYP1A2LMNACYP2A6AHRMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111269099-B Process for preparing fluorinated benzenes and fluorinated benzophenones and their derivatives 福建永晶科技股份有限公司 2023-04-07 CN claimed
CN-114835563-A Synthetic method of 4,4' -difluorobenzophenone 浙江中欣氟材股份有限公司 2022-08-02 CN claimed
US-20210292264-A1 Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2021-09-23 US claimed
US-11008273-B2 Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2021-05-18 US claimed
US-20200262776-A1 New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2020-08-20 US claimed
CN-111269099-A Process for preparing fluorinated benzenes and fluorinated benzophenones and their derivatives 福建永晶科技股份有限公司 2020-06-12 CN claimed
CN-111269099-B Process for preparing fluorinated benzenes and fluorinated benzophenones and their derivatives 福建永晶科技股份有限公司 2023-04-07 CN disclosed
CN-114835563-A Synthetic method of 4,4' -difluorobenzophenone 浙江中欣氟材股份有限公司 2022-08-02 CN disclosed
CN-114835563-A Synthetic method of 4,4' -difluorobenzophenone 浙江中欣氟材股份有限公司 2022-08-02 CN disclosed
US-20210292264-A1 Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2021-09-23 US disclosed
US-11008273-B2 Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2021-05-18 US disclosed
US-20200262776-A1 New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2020-08-20 US disclosed
CN-111269099-A Process for preparing fluorinated benzenes and fluorinated benzophenones and their derivatives 福建永晶科技股份有限公司 2020-06-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11008273-B2 Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof PFAS, PFKFB4, PFKFB2 CYP1A2 75/4885LMNA 1706/4885CYP2A6 177/4885
US-20200262776-A1 New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof PFAS, PFKFB4, PFKFB1 CYP1A2 83/4885LMNA 1886/4885CYP2A6 227/4885
US-20210292264-A1 Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof PFAS, PFKFB4, PFKFB2 CYP1A2 90/4885LMNA 1939/4885CYP2A6 215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.