Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | GRK2 | P25098 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272404 | 0.86 | ALDH1A1 (0.71) | ALDH1A1POLBTSHRTP53THRB | |
| SCHEMBL9141729 | 0.85 | ALDH1A1 (0.70) | ALDH1A1POLBTSHRTP53THRB | |
| SCHEMBL7589405 | 0.84 | MEN1 (0.59) | ALDH1A1POLBTSHRMAPTHTT | |
| SCHEMBL15232991 | 0.83 | THRB (0.49) | ALDH1A1POLBTSHRGRK2TP53 | |
| SCHEMBL15232996 | 0.82 | CCR2 (0.48) | ALDH1A1POLBTSHRGRK2TP53 | |
| SCHEMBL31681384 | 0.81 | ALDH1A1 (0.65) | ALDH1A1POLBTSHRTP53THRB | |
| SCHEMBL16060031 | 0.81 | ALDH1A1 (0.64) | ALDH1A1POLBTSHRTP53THRB | |
| SCHEMBL3081594 | 0.80 | ALDH1A1 (0.71) | ALDH1A1POLBTSHRTHRBMAPT | |
| SCHEMBL2888431 | 0.78 | MCL1 (0.49) | ALDH1A1TP53THRBMAPTHTT | |
| SCHEMBL15145878 | 0.77 | MEN1 (0.52) | ALDH1A1POLBTP53MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3923944-A1 | SPT5 INHIBITORS AND USES THEREOF | Yeda Research and Development Co. Ltd (IL) | 2021-12-22 | — | — | EP | disclosed |
| US-20210379060-A1 | SPT5 INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2021-12-09 | — | — | US | disclosed |
| WO-2020165907-A9 | SPT5 INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2021-06-10 | — | — | WO | disclosed |
| WO-2020165907-A1 | SPT5 INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210379060-A1 | SPT5 INHIBITORS AND USES THEREOF | SUPT16H, SPTLC1, MED25 | ALDH1A1 4510/4885POLB 116/4885TSHR 3321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.