Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30880140 | 1.00 | MAPT (0.54) | MAPTSIRT6LMNAALDH1A1TSHR | |
| SCHEMBL22236053 | 0.90 | ALDH1A1 (0.46) | MAPTSIRT6LMNAALDH1A1TSHR | |
| SCHEMBL956959 | 0.88 | MAOA (0.48) | MAPTSIRT6LMNAALDH1A1TSHR | |
| SCHEMBL25725414 | 0.85 | LMNA (0.58) | MAPTLMNAALDH1A1MAOAMAOB | |
| SCHEMBL375370 | 0.85 | SIRT6 (0.51) | MAPTSIRT6LMNAALDH1A1MAOA | |
| SCHEMBL16514882 | 0.84 | MAOA (0.45) | MAPTSIRT6LMNAALDH1A1TDP1 | |
| SCHEMBL22348729 | 0.83 | ALDH1A1 (0.45) | MAPTSIRT6LMNAALDH1A1TSHR | |
| SCHEMBL375364 | 0.83 | SIRT6 (0.57) | MAPTSIRT6LMNAALDH1A1TDP1 | |
| SCHEMBL29446151 | 0.83 | SIRT6 (0.57) | MAPTSIRT6LMNAALDH1A1TDP1 | |
| SCHEMBL20982501 | 0.81 | MAPT (0.58) | MAPTSIRT6LMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113795256-B | FGFR inhibitors for treatment of cancer | 布里奇恩生物科学公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-3923947-A1 | FGFR INHIBITORS FOR THE TREATMENT OF CANCER | Bridgene Biosciences, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020168237-A1 | FGFR INHIBITORS FOR THE TREATMENT OF CANCER | BRIDGENE BIOSCIENCES, INC. (US) | 2020-08-20 | — | — | WO | disclosed |